Document Detail

The release of Met-enkephalin from the guinea-pig ileum at rest and during peristaltic activity.
MedLine Citation:
PMID:  6664225     Owner:  NLM     Status:  MEDLINE    
Segments of guinea-pig ileum maintained at an intraluminal pressure of 0cm H2O released methionine-enkephalin-like material (ME) into the bathing fluid. Elevation of intraluminal pressure to 5 cm H2O induced peristalsis and reduced ME release both in the absence and presence of naloxone (0.27 microM). Following prolonged distension, tissues developed intermittent peristaltic activity. ME release during intermittency was consistently and significantly (p less than 0.05) greater than that observed from tissues exhibiting continuous peristalsis. These results suggest that ME release is associated with nonpropulsive activity in the guinea-pig ileum.
S J Clark; T W Smith
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  33 Suppl 1     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-02     Completed Date:  1984-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
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MeSH Terms
Enkephalin, Methionine / secretion*
Gastrointestinal Motility* / drug effects
Guinea Pigs
Ileum / physiology,  secretion*
Naloxone / pharmacology
Peristalsis* / drug effects
Reg. No./Substance:
465-65-6/Naloxone; 58569-55-4/Enkephalin, Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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