| The relative safety of MRI contrast agent in acute necrotizing pancreatitis. | |
| | |
MedLine Citation:
|
PMID: 9445117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To validate the safety of gadolinium-diethylenetriamine pentaacetic acid (GD-DTPA) by measuring its effect on pancreatic capillary perfusion and acinar injury in acute pancreatitis. BACKGROUND: Contrast-enhanced computed tomography (CECT) is proposed as a gold standard for early evaluation of acute necrotizing pancreatitis. However, iodinated contrast media used for CECT have been shown in these circumstances to reduce pancreatic capillary flow and increase necrosis and mortality. Recent reports suggest that post-GD MRI provides images comparable to CECT in the assessment of severe acute pancreatitis. METHODS: Necrotizing pancreatitis was induced in 14 Wistar rats by intraductal glycodeoxycholic acid (10 mM/L) and intravenous caerulein (5 microg/kg/h) over 6 hours. Intravital microscopic quantitation of pancreatic capillary blood flow was performed using fluorescein isothiocyanate-labeled erythrocytes after induction of pancreatitis and 30 and 60 minutes after an intravenous bolus of either Ringer's solution or GD-DTPA (0.2 mL/kg). RESULTS: The two study groups were comparable with regard to mean arterial pressure, heart rate, arterial blood gases, hematocrit, amylase, lipase, and trypsinogen activation peptide production throughout the experiment. GD-DTPA did not reduce capillary flow (1.93 +/- 0.05 nL/capillary/min) compared to animals infused with Ringer's solution (1.90 +/- 0.06 nL/capillary/min). CONCLUSIONS: Intravenous injection of GD-DTPA does not further impair pancreatic microcirculation or increase acinar injury in acute necrotizing pancreatitis. Because of this advantage over CT contrast medium, further development of MRI as a staging tool in acute pancreatitis seems desirable. |
| | |
Authors:
|
J Werner; J Schmidt; A L Warshaw; M M Gebhard; C Herfarth; E Klar |
Related Documents
:
|
6479687 - Pancreatography in chronic pancreatitis: international definitions. 14607647 - Early intrajejunal nutrition: bacterial translocation and gut barrier function of sever... 1797067 - Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water. 3255007 - A new quantitative model of total endolymph flow in the system of semicircular ducts. 7994897 - Bipolar diathermy tonsillectomy. 7912237 - Transcranial doppler sonography in headache-free migraineurs. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Annals of surgery Volume: 227 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1998 Jan |
Date Detail:
|
Created Date: 1998-02-05 Completed Date: 1998-02-05 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 105-11 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, University of Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Drug Evaluation, Preclinical Drug Monitoring Erythrocytes Gadolinium DTPA / diagnostic use*, pharmacokinetics Hemodynamics / drug effects Isothiocyanates Magnetic Resonance Imaging* Male Microcirculation / drug effects Pancreatitis, Acute Necrotizing / diagnosis*, physiopathology Rats Rats, Wistar Severity of Illness Index Tomography, X-Ray Computed / adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Isothiocyanates; 3129-90-6/isothiocyanic acid; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced expression of TGF-betas and their receptors in human acute pancreatitis.
Next Document: Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular fu...