Document Detail


The relative potencies of some substituted salicylic acids as metabolic stimulants in the intact rat.
MedLine Citation:
PMID:  13618547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of eighteen substituted benzoic acids on the rate of oxygen consumption have been studied in rats. 2:3-Dihydroxybenzoic acid, phthalic acid and 6-methylsalicylic acid were, at the doses used, inactive; m- and p-hydroxybenzoic acid, 2:4-, 2:5-, 2:6-, 3:4-, and 3:5-dihydroxybenzoic acid, o-aminobenzoic acid, salicyluric acid, salicylamide and 5-aminosalicylic acid decreased the rate of oxygen consumption. Only salicylic acid and o-, m- and p-cresotic acid (3-, 4- and 5-methylsalicylic acid respectively) increased the rate of oxygen consumption. Molar potency ratios of the cresotic acids as metabolic stimulants relative to salicylic acid were determined; o-cresotic acid was the most powerful with a ratio of 2.61, m- and pcresotic acid had values of 1.78 and 1.89 respectively. Two possible explanations of the higher potencies of the cresotic acids were considered. No difference in the primary action of the drug was established by determining the effect on rate of oxygen consumption of a mixture of o-cresotic and salicylic acids. An alternative possibility was that the rates of detoxication and excretion of the cresotic acids differed among themselves and from salicylic acid. No such differences were found.
Authors:
M M ANDREWS
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  13     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1958 Dec 
Date Detail:
Created Date:  1959-12-01     Completed Date:  2000-07-01     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Metabolism / drug effects*
Salicylic Acids*
Chemical
Reg. No./Substance:
0/Salicylic Acids
Comments/Corrections

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