Document Detail


The relative influences of priors and sensory evidence on an oculomotor decision variable during perceptual learning.
MedLine Citation:
PMID:  18753326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Choice behavior on simple sensory-motor tasks can exhibit trial-to-trial dependencies. For perceptual tasks, these dependencies reflect the influence of prior trials on choices that are also guided by sensory evidence, which is often independent across trials. Here we show that the relative influences of prior trials and sensory evidence on choice behavior can be shaped by training, such that prior influences are strongest when perceptual sensitivity to the relevant sensory evidence is weakest and then decline steadily as sensitivity improves. We trained monkeys to decide the direction of random-dot motion and indicate their decision with an eye movement. We characterized sequential dependencies by relating current choices to weighted averages of prior choices. We then modeled behavior as a drift-diffusion process, in which the weighted average of prior choices provided an additive offset to a decision variable that integrated incoming motion evidence to govern choice. The average magnitude of offset within individual training sessions declined steadily as the quality of the integrated motion evidence increased over many months of training. The trial-by-trial magnitude of offset was correlated with signals related to developing commands that generate the oculomotor response but not with neural activity in either the middle temporal area, which represents information about the motion stimulus, or the lateral intraparietal area, which represents the sensory-motor conversion. The results suggest that training can shape the relative contributions of expectations based on prior trends and incoming sensory evidence to select and prepare visually guided actions.
Authors:
Joshua I Gold; Chi-Tat Law; Patrick Connolly; Sharath Bennur
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-08-27
Journal Detail:
Title:  Journal of neurophysiology     Volume:  100     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-04-20     Revised Date:  2013-12-10    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2653-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Association Learning / physiology*
Behavior, Animal
Decision Making / physiology*
Discrimination (Psychology)*
Electric Stimulation / methods
Evoked Potentials, Visual / physiology
Eye Movements / physiology*
Female
Frontal Lobe / radiation effects
Macaca mulatta
Male
Models, Statistical
Motion Perception / physiology*
Photic Stimulation / methods
Psychometrics
Reaction Time / physiology
Visual Fields / physiology
Grant Support
ID/Acronym/Agency:
EY-015260/EY/NEI NIH HHS; MH-062196/MH/NIMH NIH HHS; P30 EY-001583/EY/NEI NIH HHS; R01 EY015260/EY/NEI NIH HHS; R01 EY015260-01A1/EY/NEI NIH HHS; R01 EY015260-02/EY/NEI NIH HHS; R01 EY015260-03/EY/NEI NIH HHS; R01 EY015260-04/EY/NEI NIH HHS; R01 EY015260-05/EY/NEI NIH HHS; //Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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