Document Detail

The relative importance of intramedullary, intracortical, and extraosseous soft-tissue blood flow to the repair of devascularized canine tibial cortex.
MedLine Citation:
PMID:  9188979     Owner:  NLM     Status:  MEDLINE    
Previous studies have not quantified the relative contributions of intracortical and extracortical perfusion to cortical porosity and new bone formation. The current study was performed to determine the relative importance of intramedullary, intracortical, and extraosseous soft-tissue blood flow and type of tissue to the repair of devascularized canine tibial cortex. A 2.5-cm segment of tibia between two standardized osteotomies was devascularized. The segment was replaced anatomically and stabilized with a plate. The animals were divided randomly into two groups: skin coverage (N = 8) and muscle coverage (N = 8). Thirty-one days postoperatively, cerium141 microspheres were injected, prior to sacrifice, to measure blood flow. Extraosseous soft-tissue perfusion was the same in the skin coverage and muscle flap coverage groups. There was no relationship between intramedullary or extraosseous soft-tissue flow and depth of new bone formation and cortical porosity. Intracortical blood flow was directly related to depth of new bone formation (p = 0.0006) and cortical porosity (outer cortex, p = 0.001; inner cortex, p = 0.0001). These findings indicate that the cortical repair process is linked to the restoration of perfusion and that muscle coverage, rather than the quantity of blood flow, determines the extent of cortical repair.
E H Schemitsch; J A Weinberg; M D McKee; R R Richards
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  38     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-12     Completed Date:  1997-08-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-31     Citation Subset:  IM    
Musculoskeletal Research Laboratory, St. Michael's Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Blood Flow Velocity / physiology
Bone Density / physiology
Bone Regeneration / physiology*
Regional Blood Flow / physiology
Surgical Flaps / physiology*
Tibia / blood supply*
Wound Healing / physiology

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