| The relative impact of different measures of adiposity on markers of early atherosclerosis. | |
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MedLine Citation:
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PMID: 17045678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although there are several methods available to assess adiposity, there is still controversy on the relative clinical utility of each of these methods. This study examines the relative impact of different measures of adiposity on markers of early atherosclerosis. In particular weight changes over time have been poorly assessed in this setting. METHODS: Eighty-six healthy individuals (31 men, age 36.5+/-8.9 years) with a wide range of body-mass index (28.7+/-7.0, 18.9-57.9 kg/m2) without hypertension, diabetes or smoking were examined. In addition to waist circumference and waist-to-hip ratio self-reported weight change since adolescence was also calculated. Ultrasonography was used to measure abdominal fat layers and their ratio. Flow-mediated dilatation of the brachial artery, serum levels of intercellular adhesion molecule (sICAM-1) and mean intima-media thickness of the carotid artery were measured as markers of early atherosclerosis. RESULTS: Stepwise multivariate regression analysis showed waist circumference and waist-to-hip ratio as the only independent predictor of flow-mediated dilatation. Waist circumference and weight change but not current body-mass index were independent predictors of intima-media thickness. These correlations were not influenced by ultrasonographically measured fat layers, C-reactive protein and basal insulin resistance. Body-mass index and weight gain were associated with sICAM-1 but not independently of basal insulin resistance and C-reactive protein. CONCLUSIONS: Waist circumference and weight gain were the strongest predictors of early atherosclerosis in a population of apparently healthy adults. The ultrasonographically measured fat layers did not provide additional information in this population. |
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Authors:
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Kimon S Stamatelopoulos; John P Lekakis; Georgia Vamvakou; Paraskevi Katsichti; Athanasios Protogerou; Ioanna Revela; Kalliopi Karatzi; Maria Alevizaki; Nikolaos Zakopoulos; Christos M Papamichael |
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Publication Detail:
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Type: Journal Article Date: 2006-10-11 |
Journal Detail:
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Title: International journal of cardiology Volume: 119 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-04 Completed Date: 2007-06-28 Revised Date: 2009-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-46 Citation Subset: IM |
Affiliation:
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Vascular laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece. stamatelopoulosk@yahoo.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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ultrasonography Adiposity Adult Atherosclerosis / pathology*, ultrasonography Biological Markers / analysis* Blood Flow Velocity Body Mass Index Brachial Artery / ultrasonography C-Reactive Protein / metabolism Female Humans Intercellular Adhesion Molecule-1 / blood Male Predictive Value of Tests Regression Analysis Tunica Intima / pathology Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2009 Feb 20;132(2):263-4; author reply 264-5
[PMID:
17651829
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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