| The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression. | |
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MedLine Citation:
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PMID: 18550224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our understanding of the central regulation of food intake and body weight has increased tremendously through implication of a high number of neuropeptides. However, lack of all-embracing studies have made comparison difficult in the past. The objective of this study was to demonstrate the relative importance of the different neuropeptides in terms of involvement in appetite regulatory mechanisms. We quantified expression levels of 21 hypothalamic neuropeptides and circulating levels of leptin, insulin, corticosterone, adrenocorticotropic hormone, ghrelin and adiponectin in rats after acute food deprivation and chronic food restriction using validated quantitative real-time PCR and hormone measurements. Body weight, insulin and leptin were reduced whereas corticosterone was increased by both acute food deprivation and chronic food restriction. Our results confirmed the relative importance in body weight homeostasis of neuropeptide Y and proopiomelanocortin, which were increased and decreased as predicted. The expression of other neuropeptides previously attributed central roles in body weight homeostasis, e.g. melanin-concentrating hormone and orexin, appeared to be less affected by the treatments. Moreover, the expression of dynorphin, galanin-like peptide and neuropeptide B was dramatically reduced after both treatments. This suggests that the latter neuropeptides--although previously known to be involved in body weight homeostasis--may be of unexpected importance in states of negative energy balance. |
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Authors:
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Andreas Johansson; Robert Fredriksson; Sonja Winnergren; Anna-Lena Hulting; Helgi B Schiöth; Jonas Lindblom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-04 |
Journal Detail:
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Title: Peptides Volume: 29 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 1588-95 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Uppsala University, Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Dynorphins / blood Energy Intake / physiology* Food Deprivation / physiology* Galanin-Like Peptide / blood Hormones / blood* Hypothalamus / metabolism* Male Neuropeptides / biosynthesis*, blood Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Galanin-Like Peptide; 0/Hormones; 0/Neuropeptides; 0/neuropeptide B; 74913-18-1/Dynorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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