| The relative efficacy of 0.1% and 0.2% delmopinol mouthrinses in inhibiting the development of supragingival dental plaque and gingivitis in man. | |
| | |
MedLine Citation:
|
PMID: 8046559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Delmopinol, a 3-alkyl substituted N-hydroethyl morpholine, has shown potential as a mouthrinse for the management of dental plaque and treatment of gingivitis. Delmopinol has been shown to possess plaque inhibitory activity in several previous studies. The aims of this study were to: 1) compare the antiplaque, antigingivitis efficacy and safety of 0.1% and 0.2% delmopinol-containing mouthrinses (DMP) in a 2-week, randomized, parallel arm, vehicle controlled study; and 2) determine if a dose response antiplaque, antigingivitis effect could be found in this type of formulation. One hundred and thirty-three male subjects were randomly assigned to one of three groups, 0.1% DMP, 0.2% DMP, or vehicle control mouthrinses. At baseline all subjects received a clinical examination consisting of an intraoral soft tissue, plaque (Turesky modification of Quigley-Hein plaque index), and gingival index (modified gingival index) evaluations, and received a thorough oral prophylaxis. All subjects refrained from all forms of oral hygiene for the next 2 weeks, except for the use of the assigned mouthrinse. Subjects rinsed for 1 minute with their assigned mouthrinse twice daily under supervision for 2 weeks. Following 2 weeks of mouthrinse use, plaque and gingivitis scoring and soft tissue examinations were repeated. The results showed the mean plaque index at the 2-week examination was statistically related to the baseline value (P < 0.0003, ANOVA) and the concentration of DMP (P < 0.0001, ANOVA). In contrast, the gingivitis index was not related to the concentration of DMP (P > 0.05, ANOVA). No adverse effects were noted or reported during this clinical trial. |
| | |
Authors:
|
D M Abbott; J C Gunsolley; T E Koertge; E L Payne |
Related Documents
:
|
18765809 - Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young... 8087679 - The effectiveness of three different strengths of chlorhexidine mouthrinse. 1960249 - Clinical trial in adults of an antimicrobial varnish for reducing mutans streptococci. 11766799 - Real-time control of an immobilized-cell reactor for wastewater treatment using orp. 3891959 - Periodontal disease treatment by local drug delivery. 11542299 - Color measurement as a means of quantifying surface biofouling. 41449 - Inefficacy of digitalis in the control of heart rate in patients with chronic atrial fi... 23360149 - Shoe cleat position during cycling and its effect on subsequent running performance in ... 23044259 - Exercise capacity is the strongest predictor of mortality in patients with peripheral a... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of periodontology Volume: 65 ISSN: 0022-3492 ISO Abbreviation: J. Periodontol. Publication Date: 1994 May |
Date Detail:
|
Created Date: 1994-09-01 Completed Date: 1994-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 437-41 Citation Subset: D; IM |
Affiliation:
|
Department of Periodontics, Virginia Commonwealth University, Richmond. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analysis of Variance Dental Plaque / prevention & control* Double-Blind Method Gingivitis / prevention & control* Humans Male Middle Aged Morpholines / therapeutic use* Mouthwashes / therapeutic use* Periodontal Index Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
|
0/Morpholines; 0/Mouthwashes; 79874-76-3/delmopinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of platelet-derived growth factor on the cellular response of the periodontium: an autora...
Next Document: Factitious gingival ulceration: as presenting sign of Munchausen's syndrome?