Document Detail

The relationships between air exposure, negative pressure, and hemolysis.
MedLine Citation:
PMID:  19730004     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to describe the hemolytic effects of both negative pressure and an air-blood interface independently and in combination in an in vitro static blood model. Samples of fresh ovine or human blood (5 ml) were subjected to a bubbling air interface (0-100 ml/min) or negative pressure (0-600 mm Hg) separately, or in combination, for controlled periods of time and analyzed for hemolysis. Neither negative pressure nor an air interface alone increased hemolysis. However, when air and negative pressure were combined, hemolysis increased as a function of negative pressure, the air interface, and time. Moreover, when blood samples were exposed to air before initiating the test, hemolysis was four to five times greater than samples not preexposed to air. When these experiments were repeated using freshly drawn human blood, the same phenomena were observed, but the hemolysis was significantly higher than that observed in sheep blood. In this model, hemolysis is caused by combined air and negative pressure and is unrelated to either factor alone.
Joshua R Pohlmann; John M Toomasian; Claire E Hampton; Keith E Cook; Gail M Annich; Robert H Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  55     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-11-17     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-73     Citation Subset:  IM    
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MeSH Terms
Extracorporeal Circulation / adverse effects
Hemolysis / physiology*
Hydrogen-Ion Concentration
Grant Support
R01 HD015434/HD/NICHD NIH HHS; R01 HD015434-25A1/HD/NICHD NIH HHS; R01 HD015434-25A1/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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