Document Detail


The relationships between air exposure, negative pressure, and hemolysis.
MedLine Citation:
PMID:  19730004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to describe the hemolytic effects of both negative pressure and an air-blood interface independently and in combination in an in vitro static blood model. Samples of fresh ovine or human blood (5 ml) were subjected to a bubbling air interface (0-100 ml/min) or negative pressure (0-600 mm Hg) separately, or in combination, for controlled periods of time and analyzed for hemolysis. Neither negative pressure nor an air interface alone increased hemolysis. However, when air and negative pressure were combined, hemolysis increased as a function of negative pressure, the air interface, and time. Moreover, when blood samples were exposed to air before initiating the test, hemolysis was four to five times greater than samples not preexposed to air. When these experiments were repeated using freshly drawn human blood, the same phenomena were observed, but the hemolysis was significantly higher than that observed in sheep blood. In this model, hemolysis is caused by combined air and negative pressure and is unrelated to either factor alone.
Authors:
Joshua R Pohlmann; John M Toomasian; Claire E Hampton; Keith E Cook; Gail M Annich; Robert H Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  55     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-11-17     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Air*
Animals
Extracorporeal Circulation / adverse effects
Hemolysis / physiology*
Humans
Hydrogen-Ion Concentration
Pressure*
Sheep
Time
Grant Support
ID/Acronym/Agency:
R01 HD015434/HD/NICHD NIH HHS; R01 HD015434-25A1/HD/NICHD NIH HHS; R01 HD015434-25A1/HD/NICHD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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