| The relationships of ABCB1 3435C>T and CYP2B6 516G>T with high-density lipoprotein cholesterol in HIV-infected patients receiving Efavirenz. | |
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MedLine Citation:
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PMID: 19474786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are associated with a favorable increase in high-density lipoprotein cholesterol (HDL-c) level. Isolated studies have found a direct correlation between efavirenz (EFV) exposure and HDL-c level changes. Here we explore the impact that drug disposition variants associated with EFV exposure have on changes in HDL-c level. Seventy-six patients on first-line EFV-based regimens were genotyped for CYP2B6 516G>T and ABCB1 3435C>T. There was a 37% increase (+0.32 mmol/l, P < 0.001) in mean HDL-c level over 48 weeks, and this was univariately associated with gender (male +0.26 mmol/l, female +0.55 mmol/l; P = 0.03), ABCB1 3435C>T (CC +0.26 mmol/l, CT +0.16 mmol/l, TT +0.54 mmol/l; P(ANOVA) = 0.003) and CYP2B6 516 G>T (GG +0.27 mmol/l, GT +0.29 mmol/l, TT +0.72 mmol/l; P(ANOVA) = 0.08). There was a significant association between the cumulative number of predictive genotypes (CYP2B6 516TT or ABCB1 3435TT) and mean HDL-c level change: (group 0 +0.20 mmol/l, group 1 +0.47 mmol/l, group 2 +1.00 mmol/l; P(ANOVA) < 0.0001). These findings need to be validated in independent cohorts. |
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Authors:
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T W Mahungu; D Nair; C J Smith; D Egan; M Youle; M A Johnson; S H Khoo; D J Back; A Owen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-27 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 86 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-21 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 204-11 Citation Subset: AIM; IM |
Affiliation:
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Department of HIV Medicine, Royal Free NHS Trust, London, UK. wambura@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / blood, pharmacology*, therapeutic use Aryl Hydrocarbon Hydroxylases / genetics* Benzoxazines / blood, pharmacology*, therapeutic use Cholesterol, HDL / blood* Female Genotype HIV Infections / blood*, drug therapy*, ethnology Humans Male Middle Aged Multivariate Analysis Oxidoreductases, N-Demethylating / genetics* P-Glycoprotein / genetics* Polymorphism, Single Nucleotide* Reverse Transcriptase Inhibitors / blood, pharmacology*, therapeutic use Sex Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/ABCB1 protein, human; 0/Anti-HIV Agents; 0/Benzoxazines; 0/Cholesterol, HDL; 0/P-Glycoprotein; 0/Reverse Transcriptase Inhibitors; 154635-17-3/efavirenz; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/S-mephenytoin N-demethylase; EC 1.5.-/Oxidoreductases, N-Demethylating |
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