Document Detail

The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension.
MedLine Citation:
PMID:  3889027     Owner:  NLM     Status:  MEDLINE    
In the Hypertension Detection and Follow-up Program (HDFP), elevated blood pressure (BP) was treated by rigorous, stepped care (SC) therapy among half the participants, while the other half were referred to usual sources of care (referred care, RC). There was no program to reduce weight, however, some participants changed weight voluntarily over the first 2 yr, providing an opportunity to examine the role of weight change in the development of diuretic-induced hyperuricemia, hyperglycemia and hypercholesterolemia. There was a stepwise progression from decreased glucose, uric acid and cholesterol concentrations, and BP associated with maximum weight loss to increased values with maximum weight gain. In SC, systolic BP declined by 22.4% among weight-losers and by 17.1% among weight-gainers; in RC, it was 14.4 and 8.1%, respectively. The pattern in diastolic blood pressure and weight change was similar but not as marked. These findings suggest the potential importance of weight loss in enhancing effectiveness of antihypertensive drug treatment and attenuating increases in glucose, uric acid, and cholesterol associated with diuretic treatment of hypertension. The weight change analyses are based on postrandomization observations and do not reflect experimental changes.
S Heyden; N O Borhani; H A Tyroler; K A Schneider; H G Langford; C G Hames; R Hutchinson; A Oberman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of chronic diseases     Volume:  38     ISSN:  0021-9681     ISO Abbreviation:  J Chronic Dis     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-08     Completed Date:  1985-07-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985123R     Medline TA:  J Chronic Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  281-8     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / analysis*
Blood Pressure
Body Weight*
Chlorthalidone / therapeutic use
Cholesterol / blood*
Clinical Trials as Topic
Diuretics / therapeutic use*
Follow-Up Studies
Hypertension / blood,  drug therapy*,  physiopathology
Random Allocation
Time Factors
Uric Acid / blood*
Grant Support
N01-HV-12433-42/HV/NHLBI NIH HHS; N01-HV-22931, 37-39, 45/HV/NHLBI NIH HHS; N01-HV-32933/HV/NHLBI NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Diuretics; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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