Document Detail

The relationship of systemic right ventricular function to ECG parameters and NT-proBNP levels in adults with transposition of the great arteries late after Senning or Mustard surgery.
MedLine Citation:
PMID:  20720248     Owner:  NLM     Status:  In-Process    
AIMS: Heart failure is common late after Senning or Mustard palliation of transposition of the great arteries (TGA). Although cardiac magnetic resonance (CMR) is the gold standard for evaluating systemic right ventricular performance, additional information regarding heart failure status might be gleaned from the surface ECG and circulating N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. The interrelationships between these heart failure markers were examined in adults late after Mustard and Senning surgery.
METHODS: Thirty-five consecutive adults with Senning or Mustard repair of TGA attending a dedicated congenital heart failure clinic were studied. Assessment included symptom assessment, venous blood sampling for measurement of circulating NT-proBNP levels, surface 12-lead ECG and CMR for the assessment of right ventricular systolic function and determination of indexed right ventricular volumes.
RESULTS: Mean age was 29 ± 6.5 years, 54% had undergone Mustard surgery. Compared with those with uncomplicated surgery, patients with complex surgical history had higher NT-proBNP levels (55 ± 26 vs 20 ± 35 pmol/l; p=0.002) and longer QRS duration (116 ± 28 ms vs 89 ± 11 ms; p=0.0004) while showing no difference in New York Heart Association class and right ventricular function. There was a significant relationship between diastolic and systolic right ventricular volumes and both NT-proBNP levels (r=0.43, p=0.01; r=0.53, p=0.001, respectively) and QRS duration (r=0.47, p=0.004; r=0.53, p=0.001, respectively).
CONCLUSIONS: Circulating NT-proBNP levels and several surface ECG parameters constitute safe, cost-effective and widely available surrogate markers of systemic right ventricular function and provide additional information on heart failure status. Both measures hold promise as prognostic markers and their association with long-term outcome should be determined.
Carla M Plymen; Marina L Hughes; Nathalie Picaut; Vasileios F Panoulas; Simon T Macdonald; Seamus Cullen; John E Deanfield; Fiona Walker; Andrew M Taylor; Pier D Lambiase; Aidan P Bolger
Related Documents :
19633758 - Use of natriuretic peptide assay in dyspnea.
19685518 - N-terminal pro-b-type natriuretic peptide and inducible ischemia in the heart and soul ...
19553828 - Interleukin-6 and tumor necrosis factor-alpha as biochemical markers of heart failure: ...
16046188 - Mitral annular motion as a surrogate for left ventricular function: correlation with br...
19952468 - Analysis of myocardial infarction time course in women compared with men in upper siles...
16814648 - Determinants of coronary steal in chronic total coronary occlusions donor artery, colla...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-18
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1569-73     Citation Subset:  AIM; IM    
The Division of Adult Congenital Heart Disease, The Heart Hospital, University CollegeLondon Hospitals NHS Foundation Trust, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support
//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of telepharmacy in a multihospital health system.
Next Document:  Long-term clinical outcome of extensive pulmonary vein isolation-based catheter ablation therapy in ...