| The relationship and prognostic impact of low-T3 syndrome and NT-pro-BNP in cardiovascular patients. | |
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MedLine Citation:
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PMID: 19423177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Low-T3 syndrome is highly prevalent and independently prognostic in cardiovascular patients. The relationship and prognostic impact with the cardiac marker NT-pro-BNP have not been thoroughly investigated. METHODS: Thyroid hormone levels and NT-pro-BNP were assessed in 615 consecutive patients hospitalized for cardiovascular disease. Patients with primary overt or latent thyroid disorder, hormone replacement, thyreostatic and amiodarone therapy were excluded. The association with and predictive impact on mortality were examined. RESULTS: 36 (7.1%) patients had low-T3 syndrome. After adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95%CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95%CI 1.4-6.3) were predictive for mortality after adjustment for NT-pro-BNP levels and other cardiovascular prognostic variables. In patients with fT3 levels within the normal range, fT3 and NT-pro-BNP stratified by median values showed complementary prognostic information with the highest risk for mortality in patients with low normal fT3 and high NT-pro-BNP (HR 10.5, 95%CI 3.2-34.6). CONCLUSIONS: fT3 and low-T3 syndrome are significantly related to NT-pro-BNP in patients with cardiovascular disease, but are predictors of mortality independently of NT-pro-BNP and other known cardiovascular risk parameters. |
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Authors:
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Roman Pfister; Nicole Strack; Klaus Wielckens; Gebhart Malchau; Erland Erdmann; Christian A Schneider |
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Publication Detail:
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Type: Journal Article Date: 2009-05-07 |
Journal Detail:
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Title: International journal of cardiology Volume: 144 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 187-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department III of Internal Medicine, Herzzentrum, University of Cologne, Kerpenerstr. 62, 50937 Cologne, Germany. roman.pfister@uk-koeln.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiovascular Diseases / blood*, complications*, mortality Euthyroid Sick Syndromes / blood*, complications*, mortality Female Humans Male Middle Aged Natriuretic Peptide, Brain / blood* Peptide Fragments / blood* Prognosis Thyroid Hormones / blood |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Thyroid Hormones; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
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