Document Detail


The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
MedLine Citation:
PMID:  23188068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Docetaxel-related neutropenia was associated with polymorphisms in the drug transporters ABCC2 and SLCO1B3 in Japanese cancer patients. We hypothesized that this association is because of reduced docetaxel clearance, associated with polymorphisms in those genes. We studied 64 US cancer patients who received a single cycle of 75 mg/m of docetaxel monotherapy. We found that the ABCC2 polymorphism at rs-12762549 trended to show a relationship with reduced docetaxel clearance (P=0.048), but not with neutropenia. There was no significant association of the SLCO1B3 polymorphisms with docetaxel clearance or neutropenia. We conclude that the relationship between docetaxel-associated neutropenia and polymorphisms in drug transporters identified in Japanese patients was not confirmed in this cohort of US cancer patients.
Authors:
Lionel D Lewis; Antonius A Miller; Kouros Owzar; Robert R Bies; Svetlana Markova; Chen Jiang; Deanna L Kroetz; Merrill J Egorin; Howard L McLeod; Mark J Ratain;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pharmacogenetics and genomics     Volume:  23     ISSN:  1744-6880     ISO Abbreviation:  Pharmacogenet. Genomics     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-21     Revised Date:  2014-06-30    
Medline Journal Info:
Nlm Unique ID:  101231005     Medline TA:  Pharmacogenet Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Copyright Information:
© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Agents / adverse effects,  pharmacokinetics*
Female
Humans
Male
Metabolic Clearance Rate
Middle Aged
Multidrug Resistance-Associated Proteins / genetics*
Neoplasms / complications,  drug therapy*,  genetics
Neutropenia / chemically induced,  genetics*
Organic Anion Transporters, Sodium-Independent / genetics*
Pharmacogenetics
Polymorphism, Single Nucleotide / genetics*
Retrospective Studies
Taxoids / adverse effects,  pharmacokinetics*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
CA 44691/CA/NCI NIH HHS; CA03927/CA/NCI NIH HHS; CA11789/CA/NCI NIH HHS; CA21060/CA/NCI NIH HHS; CA23108/CA/NCI NIH HHS; CA31946/CA/NCI NIH HHS; CA31956/CA/NCI NIH HHS; CA31983/CA/NCI NIH HHS; CA33601/CA/NCI NIH HHS; CA37347/CA/NCI NIH HHS; CA41287/CA/NCI NIH HHS; CA45808/CA/NCI NIH HHS; CA47577/CA/NCI NIH HHS; CA59518/CA/NCI NIH HHS; CA60138/CA/NCI NIH HHS; CA77651/CA/NCI NIH HHS; CA77658/CA/NCI NIH HHS; EB001975/EB/NIBIB NIH HHS; GM61390/GM/NIGMS NIH HHS; GM61393/GM/NIGMS NIH HHS; P30 CA023108/CA/NCI NIH HHS; U01 GM061390/GM/NIGMS NIH HHS; U01 GM061393/GM/NIGMS NIH HHS; U10 CA003927/CA/NCI NIH HHS; U10 CA011789/CA/NCI NIH HHS; U10 CA021060/CA/NCI NIH HHS; U10 CA031946/CA/NCI NIH HHS; U10 CA031983/CA/NCI NIH HHS; U10 CA033601/CA/NCI NIH HHS; U10 CA041287/CA/NCI NIH HHS; U10 CA044691/CA/NCI NIH HHS; U10 CA045808/CA/NCI NIH HHS; U10 CA047577/CA/NCI NIH HHS; U10 CA059518/CA/NCI NIH HHS; U10 CA060138/CA/NCI NIH HHS; U10 CA077651/CA/NCI NIH HHS; U10 CA077658/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Multidrug Resistance-Associated Proteins; 0/Organic Anion Transporters, Sodium-Independent; 0/SLCO1B3 protein, human; 0/Taxoids; 0/multidrug resistance-associated protein 2; 15H5577CQD/docetaxel
Comments/Corrections

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