Document Detail

The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth.
MedLine Citation:
PMID:  23296459     Owner:  NLM     Status:  Publisher    
What is already known about this subject African Americans are disproportionately affected by obesity and other metabolic risk factors in comparison to White Americans. Increasing prevalence of obesity has been associated with concomitant increases in childhood hypertension, dyslipidaemia and type 2 diabetes. Oxidative stress is associated with obesity in both adults and children. What this study adds Oxidative stress is positively associated with total body fat and truncal fat, but not with body mass index (BMI) or BMI z-score in healthy youth. Oxidative stress is associated with diastolic blood pressure in African American but not in White American healthy youth. BACKGROUND: Oxidative stress is elevated in obese youth, but less is known regarding racial disparities in the relationship of oxidative stress with metabolic risk factors. OBJECTIVES: To determine the relationship between oxidative stress and metabolic risk factors, adiposity, leptin, adiponectin and cardiovascular fitness (VO(2PEAK) ) in healthy African American and White American youth. METHODS: A marker of oxidative stress (F(2) -isoprostane), validated markers of metabolic risk factors, fitness and body composition were measured in African American (n = 82) and White American (n = 76) youth (8-17 years old) recruited over a range of BMI percentiles (4th to 99th). RESULTS: F(2) -isoprostane concentration was positively correlated with percentage body fat (r = 0.198) and percentage truncal fat (r = 0.173), but was not different between African American and White American males and females (P = 0.208). African American youth had significantly higher mean systolic and diastolic blood pressure (P = 0.023 and P = 0.011, respectively), body weight, BMI percentile and Tanner stage. After adjusting for gender, age, BMI and Tanner stage, African American youth varied from White Americans in the association of F(2) -isoprostane with diastolic blood pressure (P = 0.047), but not with systolic blood pressure, triglycerides, VO(2PEAK) or homeostatic model assessment for insulin resistance (all P > 0.05). CONCLUSIONS: Oxidative stress, as measured by urinary F(2) -isoprostane concentrations, was positively associated with percent body fat and truncal fat in youth. Oxidative stress levels were similar among African American and White American youth. Among markers of the metabolic syndrome, a significant difference between African American and White American youth was demonstrated only in the association of oxidative stress with diastolic blood pressure.
J Warolin; K R Coenen; J L Kantor; L E Whitaker; L Wang; S A Acra; L J Roberts; M S Buchowski
Related Documents :
25019019 - Rational approaches to the treatment of hypertension: modification of lifestyle measures.
23388699 - High pressure luminescence spectra of camoo(4):ln(3+) (ln = pr, tb).
19265059 - Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachno...
7772429 - Halothane affects ventilatory afterdischarge in humans.
24304709 - Hypovitaminosis d and nocturnal hypertension in obese children: an interesting link.
6449369 - Effect of freon inhalation on maximal expiratoryflows and heart rhythm after treatment ...
2537699 - A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acti...
758129 - Effect of filming projection and interobserver variability on angiographic biplane left...
1800479 - Electron microscopic changes and edema after nine hours' perfusion of isolated canine h...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  Pediatric obesity     Volume:  -     ISSN:  2047-6310     ISO Abbreviation:  Pediatr Obes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101572033     Medline TA:  Pediatr Obes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity.
Department of Pediatrics, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diabetes and risk of bladder cancer among postmenopausal women in the Iowa Women's Health Study.
Next Document:  QR-Code Based Patient Tracking: a Cost-effective Option to Improve Patient Safety.