Document Detail


The relationship of erythrocyte sodium-lithium countertransport to blood pressure and metabolic abnormalities in a sample of untreated middle-aged male workers.
MedLine Citation:
PMID:  8228205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the relationship between erythrocyte sodium-lithium countertransport and blood pressure in a randomly selected sample of untreated male workers and to evaluate the influence of a set of metabolic abnormalities commonly associated with hypertension on this relationship. DESIGN: A cross-sectional investigation of a randomly selected sample of untreated male workers (n = 216, age range 21-59 years) at the Olivetti factory in Pozzuoli, Naples. METHODS: Standardized measurements of anthropometric and metabolic parameters, blood pressure and Na(+)-Li+ countertransport were performed. RESULTS: In a simple linear correlation analysis Na(+)-Li+ countertransport was directly related to plasma triglycerides and uric acid concentrations, body mass index (BMI) and systolic and diastolic blood pressure. Significantly higher values of Na(+)-Li+ countertransport were observed in the two upper quintiles of the serum triglycerides and uric acid distributions, and of the BMI distribution. Na(+)-Li+ countertransport accounted for approximately 2% of the blood pressure variation in this study population, but its contribution to the effect of metabolic covariates was not statistically significant. Hypertensive individuals with one or more metabolic abnormality had a significantly higher mean level of Na(+)-Li+ countertransport than those hypertensives who were free of such alterations. CONCLUSIONS: The results of the present study suggest that a high level of Na(+)-Li+ countertransport is more common in those hypertensive individuals who have concomitant metabolic abnormalities than in hypertensives who are free of such abnormalities.
Authors:
P Strazzullo; F P Cappuccio; M Trevisan; A Siani; G Barba; E Ragone; E Pagano; M Mancini
Related Documents :
6377825 - Effects of captopril on arterial blood pressure, plasma renin activity and vasopressin ...
2839625 - Increase in plasma ouabainlike inhibitor of na+, k+-atpase with high sodium intake in p...
3894515 - Sodium restriction lowers high blood pressure through a decreased response of the renin...
21783145 - Creep behavior of the intact and meniscectomy knee joints.
1420615 - Hemodynamic effects of continuous negative extrathoracic pressure and continuous positi...
19353775 - Treatment of obstructive sleep apnoea in samoa progressively reduces daytime blood pres...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  11     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-07     Completed Date:  1993-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  815-22     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anthropometry
Antiporters / blood*
Blood Pressure*
Body Mass Index
Erythrocytes / metabolism*
Humans
Hypertension / blood,  metabolism
Male
Middle Aged
Regression Analysis
Triglycerides / blood*
Uric Acid / blood*
Chemical
Reg. No./Substance:
0/Antiporters; 0/Triglycerides; 0/sodium-lithium countertransporter; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Erythrocyte Na+,K+,Cl- cotransport and kidney function in essential hypertension.
Next Document:  Erythrocyte Na(+)-H+ exchange activity in essential hypertensive and obese patients: role of excess ...