Document Detail


On the relationship of brain vasculature to production of neurological deficit and morphological changes following acute unilateral common carotid artery ligation in gerbils.
MedLine Citation:
PMID:  1141958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The known susceptibility of the Mongolian gerbil to cerebral infarction following unilateral carotid artery ligation has been attributed in the past to the demonstrated absences of an anastomotic supply between the anterior and posterior cerebral circulations. In a study of 34 adult gerbils exposed to such a procedure, 11, or 33%, developed severe neurological sequelae and succumbed to the procedure in less than 30 hr, whereas 23 animals survived with only minor or transient neurological signs. All animals displayed the expected lack of an anastomosis between the anterior and posterior circulations, but in addition the animals which survived the procedure were found to have a prominent early cross-connection between the anterior cerebral arteries, whereas the animals which succumbed had no such connection. Neuropathological changes in susceptible animals were apparent as early as 3 and one-half hr after ligation and consisted of edema, initially perivascular and then intraneuronal, slowed by acute necrosis. A variety of other vascular anomalies was encountered. We conclude that the peculiar susceptibility of Mongolian gerbils to cerebral infarction following acute unilateral common carotid artery ligation is not related primarily to lack o adequate collaterals between the anterior and the anterior cerebral arteries, but to the degree of adequate adequacy of communication between the anterior cerebral arteries. The critical difference may be more one of degree, i.e. the point at which the medial branches of the anterior cerebral artery fust to become anazygos vessel, rather than an actual difference in the pattern of distribution of the anterior cerebral arteries. The presence of other variation in vascular supply in a relatively small series suggests that results of similar studies of infarction and response to treatment be interpreted with caution.
Authors:
K Berry; H M Wiśniewski; L Svarzbein; S Baez
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  25     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-09-22     Completed Date:  1975-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / blood supply*
Carotid Arteries
Cerebral Arteries / anatomy & histology,  pathology
Cerebrovascular Disorders / pathology*
Disease Models, Animal*
Female
Gerbillinae* / anatomy & histology
Infarction / pathology*
Ligation
Male
Perfusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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