Document Detail


The relationship between volumetric plaque components and classical cardiovascular risk factors and the metabolic syndrome a 3-vessel coronary artery virtual histology-intravascular ultrasound analysis.
MedLine Citation:
PMID:  21596322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to analyze volumetric plaque composition of the coronary arterial tree according to the classical cardiovascular risk factors and metabolic syndrome (MS) using virtual histology-intravascular ultrasound (VH-IVUS).
BACKGROUND: It remains unclear how the cardiovascular risk factors correlate with the histological components of coronary plaques.
METHODS: "Whole vessel" VH-IVUS analysis was performed in 189 vessels of 63 patients. The components of atherosclerotic plaques were classified as fibrous, fibrofatty, necrotic core (NC), and dense calcium. Quantitative assessment of these plaque components and the presence of VH-IVUS-derived thin-cap fibroatheroma in the coronary arterial trees were compared with cardiovascular risk factors.
RESULTS: There was a significantly larger mean plaque-plus-media burden in patients with diabetes mellitus (DM) (47 ± 5% vs. 39 ± 7% in non-DM patients, p < 0.001) and MS (47 ± 4% vs. 39 ± 7% in non-MS patients, p < 0.001). DM patients had a significantly larger %NC (17.8 ± 5.6% vs. 12.5 ± 6.1%, p = 0.003) compared with non-DM patients; and MS patients had a significantly larger %NC (17.3 ± 5.8% vs. 12.8 ± 6.2%, p = 0.016) as compared to non-MS patients. Finally, VH-IVUS-derived thin-cap fibroatheromas were more frequent in DM patients (3.4 ± 2.0 vs. 2.1 ± 1.7 in non-DM patients, p = 0.016) and in MS patients (4.1 ± 2.1 vs. 1.9 ± 1.4 in non-MS patients, p = 0.001).
CONCLUSIONS: Three-vessel VH-IVUS analysis showed that DM and MS patients, compared to patients without DM or MS, had a larger plaque-plus-media burden, larger amount of NC, and more frequent VH-IVUS-derived thin-cap fibroatheromas in coronary arterial trees, implying greater plaque vulnerability in DM and MS patients.
Authors:
Mingri Zheng; So-Yeon Choi; Seung-Jea Tahk; Hong-Seok Lim; Hyoung-Mo Yang; Byoung-Joo Choi; Myeong-Ho Yoon; Jin-Sun Park; Gyo-Seung Hwang; Joon-Han Shin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  4     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-20     Completed Date:  2011-09-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Chi-Square Distribution
Coronary Stenosis / etiology,  ultrasonography*
Coronary Vessels / ultrasonography*
Diabetes Complications / etiology,  ultrasonography*
Female
Humans
Image Interpretation, Computer-Assisted*
Imaging, Three-Dimensional*
Male
Metabolic Syndrome X / complications*
Middle Aged
Plaque, Atherosclerotic / etiology,  ultrasonography*
Predictive Value of Tests
Prospective Studies
Regression Analysis
Republic of Korea
Risk Assessment
Risk Factors
Severity of Illness Index
Ultrasonography, Interventional*
Comments/Corrections
Comment In:
JACC Cardiovasc Interv. 2011 May;4(5):511-2   [PMID:  21596323 ]

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