| The relationship between urea and pyrimidine de novo synthesis in ruminant liver. | |
| | |
MedLine Citation:
|
PMID: 3347689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of ammonia and inhibition of the urea cycle by norvaline on orotic acid synthesis in five Polish Merino ewes was investigated. The sheep were exposed to 60 min of successive infusions of 0.9% NaCl, NH4Cl (20 mumol kg-1 min-1), and NH4Cl with DL-norvaline (10 mumol kg-1 min-1) solutions administered to the mesenteric vein. The average rate of orotic acid output, urea output and ammonia uptake in the liver in control conditions (infusion of 0.9% NaCl) was: 1.09 nmol g-1 min-1, 0.97 mumol g-1 min-1 and 0.94 mumol g-1 min-1, respectively. Ammonia significantly stimulated the orotic acid output, urea output and ammonia uptake. At the same time liver uptake of glutamic acid, alanine and glycine increased. Norvaline as a competitive inhibitor of ornithine transcarbamylase depressed citrulline release and urea output in the liver, and elevated, although not significantly, the orotic acid output. It was concluded that ammonia stimulates the de novo synthesis of pyrimidine in the sheep liver but the participation in this effect of carbamyl phosphate generated in the urea cycle is limited. |
| | |
Authors:
|
T Motyl; A Orzechowski; S Pierzynowski |
Related Documents
:
|
901879 - Incorporation in vivo of 1-14c-palmitic acid into placental and fetal liver lipids of t... 15377589 - Invited review: pathology, etiology, prevention, and treatment of fatty liver in dairy ... 15685949 - Differential utilization of hepatic and myocardial fatty acids during forced molt of la... 2707549 - Effects of bile acids on liver cell injury by cultured supernatant of activated liver a... 16603729 - Lipid metabolism and liver inflammation. ii. fatty liver disease and fatty acid oxidation. 6617159 - Comparison of in vivo fatty acid synthesis of the genetically lean and fat chickens. 18498319 - Effect of lactic and citric acid on the stability of b-aflatoxins in extrusion-cooked s... 7237469 - Radiometric enzyme-inhibition technique for measuring acivicin in plasma. 1676679 - Release of endogenous glutamate and aspartate from the frog spinal cord in vitro. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Quarterly journal of experimental physiology (Cambridge, England) Volume: 73 ISSN: 0144-8757 ISO Abbreviation: Q J Exp Physiol Publication Date: 1988 Jan |
Date Detail:
|
Created Date: 1988-04-18 Completed Date: 1988-04-18 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8206873 Medline TA: Q J Exp Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
|
Department of Animal Physiology, Warsaw Agricultural University, Poland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
metabolism Ammonia / metabolism Animals Biological Transport Female Liver / metabolism* Orotic Acid / metabolism Pyrimidines / biosynthesis* Sheep / metabolism* Urea / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Pyrimidines; 57-13-6/Urea; 65-86-1/Orotic Acid; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the vicissitudes of Freud's early mothering. II: Alienation from his biological mother.
Next Document: Transport of selenate and sulphate across the intestinal brush-border membrane of pig jejunum by two...