| The relationship between unexplained elevated serum markers in triple test, uterine artery Doppler measurements and adverse pregnancy outcome. | |
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MedLine Citation:
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PMID: 20225773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship between adverse pregnancy outcomes and unexplained elevations of second trimester maternal serum human chorionic gonadotropin (hCG), alpha fetoprotein (AFP) levels and uterine artery Doppler measurements. METHODS: A total of 144 women between 16-20 weeks of gestation that applied to our clinic for triple test were enrolled into the study. Study group consisted of 84 pregnant women with hCG and/or AFP levels > or =2 MoM. Control group comprised of 60 pregnant women with hCG and AFP levels <2 MoM. Study group was further subdivided into 3 subgroups: Subgroup I; only AFP> or =2 MoM (n=30), subgroup II; only hCG > or =2 MoM (n=64) and subgroup III; both AFP and hCG > or =2 MoM (n=10). RESULT: Operative delivery rate (p = 0.0017), overall complication rate (p=0.0002), bilateral early diastolic notch presence rate (p = 0.015) were high and mean birth weight was low (p=0.045) in the study group. In subgroup I patients, low birth weight [LBW] (p = 0.0008), preterm delivery (p = 0.0001), preeclampsia (p = 0.003) and preterm premature rupture of membranes [PPROM] (p = 0.012) rates were high. In subgroup II patients, only small for gestational age baby [SGA] (p = 0.016) rate was high. In subgroup III patients LBW (p = 0.009), preterm delivery (p = 0.0001) and PPROM (p = 0.01) rates were high. According to Doppler velocimetry studies, bilateral early diastolic notch presence rate was high (p = 0.015) in the study group. CONCLUSION: Patients with high AFP levels and bilateral uterine artery diastolic notch presence, are candidates for pregnancy complications and these groups of patients should be followed up more intensively. |
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Authors:
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Ayse Yasemin Karageyim Karsidag; Esra Esim Buyukbayrak; Bulent Kars; Ugur Suyugul; Orhan Unal; Mehmet Cem Turan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: JPMA. The Journal of the Pakistan Medical Association Volume: 60 ISSN: 0030-9982 ISO Abbreviation: J Pak Med Assoc Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501162 Medline TA: J Pak Med Assoc Country: Pakistan |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: IM |
Affiliation:
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Obstetric and Gynecology Department, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Case-Control Studies Chorionic Gonadotropin / blood* Confidence Intervals Female Humans Mass Screening Pregnancy Pregnancy Complications / epidemiology* Pregnancy Outcome / epidemiology* Pregnancy Trimester, Second / blood* Rheology Risk Risk Factors Turkey Ultrasonography, Doppler Uterine Artery / ultrasonography* alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins |
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