Document Detail


The relationship between the thrombotic and infectious complications of central venous catheters.
MedLine Citation:
PMID:  8139059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess the frequency of thrombotic and infectious complications of long-term use of vascular catheters in cancer patients and to determine whether the two types of complication are related. DESIGN: Case series. SETTING: A 500-bed tertiary cancer center. PATIENTS: Seventy-two cancer patients. INTERVENTIONS: During a 16-month period, postmortem examinations of catheterized veins and contralateral uncatheterized veins were done on all patients with indwelling central venous catheters who met study criteria. MAIN OUTCOME MEASURES: Catheter-related septicemia determined by clinical and microbiological data as well as postmortem pathology; venous pathological changes such as mural hemorrhage, thrombosis, calcification, ulceration, and inflammation. RESULTS: Premortem clinical and microbiological data were obtained retrospectively on all patients. Pathological changes were noted in 35 catheterized veins (49%) compared with five contralateral control veins (9.2%) (P < .001). Mural thrombi were noted in 27 catheterized veins (38%) compared with only one contralateral control vein (1.4%) (P < .001). Other pathological changes consisted of four central venous catheter-related mural thrombi (5.6%) in the right atrium and four instances (5.6%) of nonbacterial thrombotic endocarditis, three involving the tricuspid and one the mitral valves. Seven patients had catheter-related septicemia. Of the 31 patients with mural thrombosis of the catheterized vein or right atrium, seven developed catheter-related septicemia, whereas none of the 41 patients with normal catheterized veins and atria developed catheter-related septicemia (P < .01). CONCLUSIONS: Thrombotic complications are common in catheterized veins and are often associated with catheter sepsis.
Authors:
I I Raad; M Luna; S A Khalil; J W Costerton; C Lam; G P Bodey
Related Documents :
8379329 - Difficulty in removing a percutaneous central venous catheter inserted from a periphera...
16596529 - Azygos arch cannulation by central venous catheters for hemodialysis.
7802189 - The smart needle. a new doppler ultrasound-guided vascular access needle.
18326129 - The incidence and risk of central venous catheter malpositioning: a prospective cohort ...
7726009 - Percutaneous transfemoral repositioning of malpositioned central venous catheters.
6460119 - Treatment of vasculogenic erectile dysfunction by direct anastomosis of the inferior ep...
11479499 - Valve-preserving aortic replacement: does the additional repair of leaflet prolapse adv...
11574239 - Surgical repair of coronary arteriovenous fistula: a simple and useful approach to iden...
10798419 - Congenital heart surgery nomenclature and database project: tetralogy of fallot.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA : the journal of the American Medical Association     Volume:  271     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-04-25     Completed Date:  1994-04-25     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1014-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical Specialities, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Autopsy
Catheterization, Central Venous / adverse effects*
Catheters, Indwelling / adverse effects*
Female
Heart Diseases / etiology*,  microbiology,  pathology
Humans
Male
Middle Aged
Neoplasms / therapy
Sepsis / etiology*
Thrombosis / etiology*,  microbiology,  pathology
Vascular Diseases / etiology,  pathology
Veins / microbiology,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fecal occult blood screening for colorectal cancer. Is mortality reduced by chance selection for scr...
Next Document:  Medical student abuse: an international phenomenon.