|The relationship between the thrombotic and infectious complications of central venous catheters.|
|PMID: 8139059 Owner: NLM Status: MEDLINE|
|OBJECTIVES: To assess the frequency of thrombotic and infectious complications of long-term use of vascular catheters in cancer patients and to determine whether the two types of complication are related.
DESIGN: Case series.
SETTING: A 500-bed tertiary cancer center.
PATIENTS: Seventy-two cancer patients.
INTERVENTIONS: During a 16-month period, postmortem examinations of catheterized veins and contralateral uncatheterized veins were done on all patients with indwelling central venous catheters who met study criteria.
MAIN OUTCOME MEASURES: Catheter-related septicemia determined by clinical and microbiological data as well as postmortem pathology; venous pathological changes such as mural hemorrhage, thrombosis, calcification, ulceration, and inflammation.
RESULTS: Premortem clinical and microbiological data were obtained retrospectively on all patients. Pathological changes were noted in 35 catheterized veins (49%) compared with five contralateral control veins (9.2%) (P < .001). Mural thrombi were noted in 27 catheterized veins (38%) compared with only one contralateral control vein (1.4%) (P < .001). Other pathological changes consisted of four central venous catheter-related mural thrombi (5.6%) in the right atrium and four instances (5.6%) of nonbacterial thrombotic endocarditis, three involving the tricuspid and one the mitral valves. Seven patients had catheter-related septicemia. Of the 31 patients with mural thrombosis of the catheterized vein or right atrium, seven developed catheter-related septicemia, whereas none of the 41 patients with normal catheterized veins and atria developed catheter-related septicemia (P < .01).
CONCLUSIONS: Thrombotic complications are common in catheterized veins and are often associated with catheter sepsis.
|I I Raad; M Luna; S A Khalil; J W Costerton; C Lam; G P Bodey|
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|Type: Journal Article|
|Title: JAMA Volume: 271 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1994 Apr|
|Created Date: 1994-04-25 Completed Date: 1994-04-25 Revised Date: 2014-09-17|
Medline Journal Info:
|Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES|
|Languages: eng Pagination: 1014-6 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Catheterization, Central Venous / adverse effects*
Catheters, Indwelling / adverse effects*
Heart Diseases / etiology*, microbiology, pathology
Neoplasms / therapy
Sepsis / etiology*
Thrombosis / etiology*, microbiology, pathology
Vascular Diseases / etiology, pathology
Veins / microbiology, pathology*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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