Document Detail

The relationship between systolic pressure and stroke volume describes myocardial contractility.
MedLine Citation:
PMID:  8664459     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To develop a method of measuring end-systolic elastance from information obtained outside the ventricle and thereby simplify its transduction. DESIGN: Prospective, within-animal comparative analysis. SETTING: University-based laboratory study. PARTICIPANTS: Six mixed-breed dogs. INTERVENTIONS: Instrumentation included minor axis sonomicrometry, ascending aortic flow probe, aortic and ventricular pressure transducers, and constricting cuffs on the vena cavae and aorta. MEASUREMENTS AND MAIN RESULTS: Elastance was determined from the equation PES = EES (VED - VES), where VED - VES is stroke volume and PES is end-systolic arterial pressure. EES was derived from both preload and afterload manipulation. Cardiac performance indices were calculated automatically by computer under conditions of varying load and inotropy. This extraventricular method of elastance calculation was compared by linear regression and analysis of variance to preload recruitable stroke work, traditional EES determination (using ventricular dimension instead of volume), and LVdP/dt at 50 mmHg. EES measured from the aortic sites correlated well with the other contractility indicators (p < 0.003 in all cases) and demonstrated more sensitivity and stability under loading manipulation than traditional EES. A strong relationship between the change in stroke volume and end-systolic ventricular diameter during acute aortic constriction (r = 0.924, p < 0.0001) was observed, and the mean r value for the individual outflow elastance measurements was 0.97 +/- 0.02. CONCLUSIONS: In this study, measurement of EES from the ventricular outflow tract during progressive aortic constriction produced results more consistent and descriptive than EES by traditional techniques and has the potential for obtaining elastance measurements from possibly less invasive techniques.
J A Reitan; P G Moore; N D Kien; S Lee; D A White
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  9     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-08-07     Completed Date:  1996-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  676-83     Citation Subset:  IM    
Department of Anesthesiology, University of California, Davis 95616, USA.
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MeSH Terms
Analysis of Variance
Aorta / physiology
Blood Pressure*
Cardiac Output
Heart Rate
Heart Ventricles / anatomy & histology
Linear Models
Manometry / instrumentation
Myocardial Contraction*
Prospective Studies
Stroke Volume*
Transducers, Pressure
Ultrasonography / instrumentation
Venae Cavae / physiology
Ventricular Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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