Document Detail

The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage--a historical perspective.
MedLine Citation:
PMID:  19945653     Owner:  NLM     Status:  MEDLINE    
Periventricular-intraventricular hemorrhage (PV-IVH) remains the major cause of injury to the developing brain. Predisposing factors include a germinal matrix with an immature vasculature, a pressure passive cerebral circulation, and hemodynamic perturbations in sick premature infants. Intact cerebral autoregulation has been documented in stable premature infants; however, it functions within a limited blood pressure range and is likely to be absent in the sick hypotensive infant, which increases the risk for PV-IVH with perturbations in blood pressure. The risk for PV-IVH is markedly increased in the absence of antenatal glucocorticoid exposure in the intubated low birthweight infant <1000 g with respiratory distress syndrome; +/- other complications. Although surfactant administration reduces the severity of respiratory distress syndrome, it has not led to a reduction in PV-IVH. Early postnatal administration of indomethacin has been associated with a reduction in PV-IVH, although this has not translated into long-term neurocognitive benefits.
Jeffrey M Perlman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in pediatric neurology     Volume:  16     ISSN:  1558-0776     ISO Abbreviation:  Semin Pediatr Neurol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441351     Medline TA:  Semin Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Division of Newborn Medicine, Department of Pediatrics, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY 10065, USA.
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MeSH Terms
Blood Pressure / physiology
Cerebral Hemorrhage / pathology*,  physiopathology
Cerebral Ventricles / pathology,  physiopathology*
Cerebrovascular Circulation / physiology*
Hemodynamics / physiology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases*

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