| The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage--a historical perspective. | |
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MedLine Citation:
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PMID: 19945653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Periventricular-intraventricular hemorrhage (PV-IVH) remains the major cause of injury to the developing brain. Predisposing factors include a germinal matrix with an immature vasculature, a pressure passive cerebral circulation, and hemodynamic perturbations in sick premature infants. Intact cerebral autoregulation has been documented in stable premature infants; however, it functions within a limited blood pressure range and is likely to be absent in the sick hypotensive infant, which increases the risk for PV-IVH with perturbations in blood pressure. The risk for PV-IVH is markedly increased in the absence of antenatal glucocorticoid exposure in the intubated low birthweight infant <1000 g with respiratory distress syndrome; +/- other complications. Although surfactant administration reduces the severity of respiratory distress syndrome, it has not led to a reduction in PV-IVH. Early postnatal administration of indomethacin has been associated with a reduction in PV-IVH, although this has not translated into long-term neurocognitive benefits. |
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Authors:
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Jeffrey M Perlman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in pediatric neurology Volume: 16 ISSN: 1558-0776 ISO Abbreviation: Semin Pediatr Neurol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441351 Medline TA: Semin Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 191-9 Citation Subset: IM |
Affiliation:
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Division of Newborn Medicine, Department of Pediatrics, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY 10065, USA. jmp2007@med.cornell.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology Cerebral Hemorrhage / pathology*, physiopathology Cerebral Ventricles / pathology, physiopathology* Cerebrovascular Circulation / physiology* Hemodynamics / physiology Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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