Document Detail

On the relationship between synaptic input and spike output jitter in individual neurons.
MedLine Citation:
PMID:  9012854     Owner:  NLM     Status:  MEDLINE    
What is the relationship between the temporal jitter in the arrival times of individual synaptic inputs to a neuron and the resultant jitter in its output spike? We report that the rise time of firing rates of cells in striate and extrastriate visual cortex in the macaque monkey remain equally sharp at different stages of processing. Furthermore, as observed by others, multiunit recordings from single units in the primate frontal lobe reveal a strong peak in their cross-correlation in the 10-150 msec range with very small temporal jitter (on the order of 1 msec). We explain these results using numerical models to study the relationship between the temporal jitter in excitatory and inhibitory synaptic input and the variability in the spike output timing in integrate-and-fire units and in a biophysically and anatomically detailed model of a cortical pyramidal cell. We conclude that under physiological circumstances, the standard deviation in the output jitter is linearly related to the standard deviation in the input jitter, with a constant of less than one. Thus, the timing jitter in successive layers of such neurons will converge to a small value dictated by the jitter in axonal propagation times.
P Marsálek; C Koch; J Maunsell
Related Documents :
6272624 - Virus-induced electrotonic coupling: hypothesis on the mechanism of periodic eeg discha...
9616784 - Sensory coding in cortical neurons. recent results and speculations.
8189384 - Electrophysiological characteristics of immunochemically identified rat oxytocin and va...
3585464 - Properties of proprioceptive neurons in the cuneate nucleus of the cat.
8046394 - Human immunodeficiency virus type 1 tat activity in human neuronal cells: uptake and tr...
12106154 - Differential calcium binding protein immunoreactivity distinguishes classes of relay ne...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  94     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  735-40     Citation Subset:  IM    
Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials*
Macaca mulatta
Models, Biological
Nerve Net / physiology
Neurons / physiology*
Synapses / physiology*
Synaptic Transmission*
Vision, Ocular / physiology
Visual Cortex / cytology,  physiology*
Visual Perception / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia.
Next Document:  Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10.