Document Detail


The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome.
MedLine Citation:
PMID:  19701093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Motility disturbances are involved in the pathophysiology of the irritable bowel syndrome (IBS). Population-based studies have shown an association between increasing body mass index (BMI) and different gastrointestinal (GI) symptoms. The aim of this prospective study was to characterize the relationships between symptoms in IBS, GI transit, as a measure of GI motility, and BMI.
METHODS: We included 96 IBS patients in which 34 patients had diarrhea predominance (D-IBS), 16 had predominant constipation (C-IBS) and 46 had alternating bowel habits (A-IBS). All patients completed a GI symptom questionnaire and underwent a measurement of gastric emptying, small bowel residence and colonic transit. Transit values in 83 healthy individuals served as reference. BMI was calculated.
RESULTS: At least one transit abnormality was found in 49 of 96 patients (51%). Increasing severity of urgency, loose stools and reflux were associated with higher BMI. Moreover, patients overweight had significantly faster colonic and rectosigmoid transit and higher stool frequency compared with normal weight patients. The symptom severities of pain/discomfort and bloating were associated with colonic transit abnormalities. In women, transit in the small bowel and colon was significantly slower in C-IBS compared with D-IBS.
CONCLUSION: GI transit is of relevance for the symptom pattern in patients with IBS. High BMI is associated with fast regional bowel transit and may therefore influence some stool-related symptoms in IBS.
Authors:
Riadh Sadik; Einar Björnsson; Magnus Simrén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-04     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg 41345, Sweden. riadh.sadik@vgregion.se
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Body Mass Index*
Constipation / etiology*,  physiopathology
Diarrhea / etiology*,  physiopathology
Female
Gastric Emptying / physiology
Gastrointestinal Transit / physiology*
Humans
Irritable Bowel Syndrome / complications*,  physiopathology
Male
Middle Aged
Overweight / complications,  physiopathology
Prospective Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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