Document Detail

On the relationship between seed-based and ICA-based measures of functional connectivity.
MedLine Citation:
PMID:  21394769     Owner:  NLM     Status:  MEDLINE    
Brain functional connectivity (FC) refers to inter-regional synchrony of low frequency fluctuations in blood oxygenation level dependent functional magnetic resonance imaging. FC has been evaluated both during task performance and in the "resting" state, yielding reports of FC differences correlated with behavior and diagnosis. Two methodologies are widely used for evaluating FC from blood oxygenation level dependent functional magnetic resonance imaging data: Temporal correlation with a specified seed voxel or small region of interest; and spatial independent component analysis. While results from seed-based and independent component analysis methodologies are generally similar, they are conceptually different. This study is intended to elucidate and illustrate, qualitatively and quantitatively, the relationship between seed and independent component analysis derived measures of FC. Seed-based FC measures are shown to be the sum of independent component analysis-derived within network connectivities and between network connectivities. We present a simple simulation and an experiment on visuomotor activity that highlight this relationship between the two methods.
Suresh E Joel; Brian S Caffo; Peter C M van Zijl; James J Pekar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-10
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  66     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-15     Completed Date:  2011-12-29     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Brain Mapping / methods*
Image Enhancement / methods
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Models, Theoretical
Motor Cortex / physiology*
Oxygen / blood*
Principal Component Analysis
Visual Cortex / physiology*
Grant Support
P41 EB015909/EB/NIBIB NIH HHS; P41 RR015241/RR/NCRR NIH HHS; P41 RR015241-08/RR/NCRR NIH HHS; P41 RR015241-09/RR/NCRR NIH HHS; P41-RR15241/RR/NCRR NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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