| The relationship between resting lung-to-lung circulation time and peak exercise capacity in chronic heart failure patients. | |
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MedLine Citation:
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PMID: 17602986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Peak exercise capacity (VO2peak) is a measure of the severity of chronic heart failure (CHF); however, few indices of resting cardiopulmonary function have been shown to predict VO2peak. A prolonged circulation time has been suggested as an index of increased severity of CHF. The aim of this study was to investigate the relationship between resting lung-to-lung circulation time (LLCT) and VO2peak in CHF. METHODS AND RESULTS: Thirty CHF patients (59 +/- 13 years, New York Heart Association: 1.9 +/- 1.0) undertook the study. Each subject completed resting pulmonary and echocardiography measures and an incremental exercise test. LLCT was measured using the reappearance of end-tidal acetylene (P(ET),C2H2) after a single inhalation. Univariate and multivariate stepwise linear regression was used to determine the predictors of VO2peak. Univariate correlates of VO2peak (group mean 1.53 +/- 0.44 L/min(-1)) included LLCT (r = -0.75), inspiratory capacity (r = 0.41), ejection fraction (r = 0.33), peak early flow velocity (r = -0.39), and the ratio of early to late flow velocity (r = -0.31). LLCT was the only independent predictor where VO(2peak) = 3.923-0.045 (LLCT); r2 = 54%. CONCLUSIONS: These results suggest that resting LLCT determined using the soluble inert gas technique represents a simple, noninvasive method that provides additional information regarding exercise capacity in CHF. |
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Authors:
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Norman R Morris; Eric M Snyder; Kenneth C Beck; Luke J Haseler; Lyle J Olson; Bruce D Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiac failure Volume: 13 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-07-19 Revised Date: 2011-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 389-94 Citation Subset: IM |
Affiliation:
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School of Physiotherapy and Exercise Science, Gold Coast Campus, Griffith University, Queensland, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylene
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pharmacokinetics Aged Cardiac Output / physiology Exercise Test Female Heart Failure / physiopathology* Humans Male Middle Aged Multivariate Analysis Oxygen Consumption / physiology* Pulmonary Circulation / physiology* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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HL7 14878/HL/NHLBI NIH HHS; R01 HL071478-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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74-86-2/Acetylene |
| Comments/Corrections | |
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