Document Detail

The relationship between resting lung-to-lung circulation time and peak exercise capacity in chronic heart failure patients.
MedLine Citation:
PMID:  17602986     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Peak exercise capacity (VO2peak) is a measure of the severity of chronic heart failure (CHF); however, few indices of resting cardiopulmonary function have been shown to predict VO2peak. A prolonged circulation time has been suggested as an index of increased severity of CHF. The aim of this study was to investigate the relationship between resting lung-to-lung circulation time (LLCT) and VO2peak in CHF.
METHODS AND RESULTS: Thirty CHF patients (59 +/- 13 years, New York Heart Association: 1.9 +/- 1.0) undertook the study. Each subject completed resting pulmonary and echocardiography measures and an incremental exercise test. LLCT was measured using the reappearance of end-tidal acetylene (P(ET),C2H2) after a single inhalation. Univariate and multivariate stepwise linear regression was used to determine the predictors of VO2peak. Univariate correlates of VO2peak (group mean 1.53 +/- 0.44 L/min(-1)) included LLCT (r = -0.75), inspiratory capacity (r = 0.41), ejection fraction (r = 0.33), peak early flow velocity (r = -0.39), and the ratio of early to late flow velocity (r = -0.31). LLCT was the only independent predictor where VO(2peak) = 3.923-0.045 (LLCT); r2 = 54%.
CONCLUSIONS: These results suggest that resting LLCT determined using the soluble inert gas technique represents a simple, noninvasive method that provides additional information regarding exercise capacity in CHF.
Norman R Morris; Eric M Snyder; Kenneth C Beck; Luke J Haseler; Lyle J Olson; Bruce D Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  13     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-07-19     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-94     Citation Subset:  IM    
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MeSH Terms
Acetylene / pharmacokinetics
Cardiac Output / physiology
Exercise Test
Heart Failure / physiopathology*
Middle Aged
Multivariate Analysis
Oxygen Consumption / physiology*
Pulmonary Circulation / physiology*
Severity of Illness Index
Grant Support
Reg. No./Substance:

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