Document Detail

The relationship between recent cocaine use and pregnancy outcome.
MedLine Citation:
PMID:  1876358     Owner:  NLM     Status:  MEDLINE    
We conducted urine screening for cocaine metabolite in 500 consecutive women admitted to a labor and delivery unit. The pregnancy outcome of 411 of the women was determined at that admission. The prevalence of cocaine-positive urines was 15.3% (95% confidence interval 11.8-18.8%). A subset of this population that had not received prenatal care had a prevalence of 62% (95% confidence interval 47.2-76.6%). Women with positive urines were almost four times more likely to have preterm labor and over twice as likely to deliver a premature infant or one with a 1-minute Apgar score of 6 or lower. Our findings support the concept that urine drug screening for cocaine and/or other drugs of abuse should be considered in patients who present with no prenatal care, premature labor, premature delivery, and delivery of an infant with a 1-minute Apgar score of 6 or less. This strategy may enable us to identify and bring to therapy a population of women that could potentially go unrecognized.
M R Spence; R Williams; G J DiGregorio; A Kirby-McDonnell; M Polansky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  78     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-20     Completed Date:  1991-09-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Hahnemann University School of Medicine, Philadelphia, PA.
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MeSH Terms
Apgar Score
Cocaine* / urine
Infant, Newborn
Obstetric Labor, Premature / epidemiology*
Philadelphia / epidemiology
Pregnancy Outcome / epidemiology*
Prenatal Care
Risk Factors
Substance Abuse Detection
Substance-Related Disorders / complications*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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