Document Detail


The relationship between quinolone exposures and resistance amplification is characterized by an inverted U: a new paradigm for optimizing pharmacodynamics to counterselect resistance.
MedLine Citation:
PMID:  17116679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the relationship between garenoxacin exposure and quinolone-resistant subpopulations for three bacterial isolates in an in vitro hollow-fiber infection model. An "inverted-U" relationship was identified wherein resistant subpopulations rose initially and then declined with increasing exposure, until reaching a threshold that prevented resistance amplifications. Different targets for the area under the concentration-time curve over 24 h/MIC ratio were required for different bacteria.
Authors:
Vincent H Tam; Arnold Louie; Mark R Deziel; Weiguo Liu; George L Drusano
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Publication Detail:
Type:  Journal Article     Date:  2006-11-20
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  51     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-06-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  744-7     Citation Subset:  IM    
Affiliation:
Emerging Infections and Host Defense Laboratory, Ordway Research Institute, Albany, NY, USA. vtam@uh.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / metabolism,  pharmacology*
Drug Resistance, Bacterial* / drug effects
Fluoroquinolones / metabolism,  pharmacology*
Klebsiella pneumoniae / drug effects*,  growth & development,  metabolism
Microbial Sensitivity Tests
Quinolines / metabolism,  pharmacology*
Staphylococcus aureus / drug effects*,  growth & development,  metabolism
Streptococcus pneumoniae / drug effects*,  growth & development,  metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Fluoroquinolones; 0/Quinolines; 0/garenoxacin; 91-22-5/quinoline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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