Document Detail


The relationship between pregnancy and oxidative stress markers on patients undergoing ovarian stimulations.
MedLine Citation:
PMID:  22798064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We investigated the activities and relevance of a validated panel of antioxidant enzymes, cytokines, specific lipid peroxidation end products and six fatty acids by correlational analyses with peak E(2) levels and pregnancy outcome after ovarian stimulation for IVF or IUI.
METHODS: Blood samples obtained from 15 patients undergoing ovarian stimulation with rFSH or hMG were divided into two groups. Group-1 was baseline blood collected on day-2-3 of women cycle. Group-2 is blood collected at the end of FSH/hMG injection. Serum was collected and stored in liquid nitrogen at -196 °C until analysis. Standard IVF and IUI procedures were followed. The serum levels of Paraoxonase (PON1), Superoxide Dismutases (SOD), Interleukin-6 (IL-6), Glutathione Peroxidase (GPx), 8-Isoprostane, and fatty acids Arachidic, Palmitic, Stearic, Oleic, Linoleic & Linolenic were measured.
RESULTS: With the exception of 8-Isoprostane, results showed a positive correlation between baseline and peak levels of E(2) and that of SOD, GPx, PON1, and IL-6. The PON1, IL-6 and SOD were significantly (p < 0.05) higher in pregnant than non-pregnant group. Fatty acid levels at baseline and peak E(2) were not different but pregnancy rates were found to be decreasing with higher palmitic, and stearic acid levels.
CONCLUSIONS: Ovarian stimulation causes a significant increase in serum PON1, SOD, GPx and IL-6 activity in women undergoing IVF or IUI. The high levels of IL-6, SOD, and PON1 and lower levels of palmitic, and stearic acids in the pregnancy positive group indicate that these oxidative stress and nutritional factors may be used as a predictive marker in controlled ovarian stimulation success.
Authors:
Abdelmoneim Younis; Cynthia Clower; Deanna Nelsen; William Butler; Andrew Carvalho; Eden Hok; Mahdi Garelnabi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-14
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1083-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Central Georgia Fertility Institute Macon, Mercer University School of Medicine, 4075 Elnora Dr., Macon, GA 31210, USA. moneims@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aryldialkylphosphatase / blood*
Biological Markers / analysis*
Dinoprost / analogs & derivatives,  blood
Endometriosis / complications
Estradiol / blood*
Fatty Acids / analysis,  blood
Female
Fertilization in Vitro
Glutathione Peroxidase / blood
Humans
Infertility, Female / etiology
Interleukin-6 / blood*
Lipid Peroxidation
Ovulation Induction / methods*
Oxidative Stress*
Polycystic Ovary Syndrome / complications
Predictive Value of Tests
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Prospective Studies
Sperm Injections, Intracytoplasmic
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids; 0/Interleukin-6; 27415-26-5/8-epi-prostaglandin F2alpha; 50-28-2/Estradiol; 551-11-1/Dinoprost; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human
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