| The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility. | |
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MedLine Citation:
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PMID: 17643973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patients with asthma and 214 sex and age matched healthy subjects. As previously reported, the -588C/T and -23G/T polymorphisms were completely linked. The -588TT/-23TT genotype was found to be associated with decreased risk of allergic asthma after adjustment for age, gender and smoking status using multivariate logistic regression analysis (OR=0.33 95% CI 0.15-0.70, p=0.036). However, the -588CT/-23GT genotype was associated with increased risk of non-allergic asthma (OR=2.03 95% CI 1.05-3.90, p=0.06). This is a first study reporting the association between genetic variations in the glutamate cysteine ligase gene and susceptibility to bronchial asthma. |
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Authors:
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A V Polonikov; V P Ivanov; M A Solodilova; I V Khoroshaya; M A Kozhuhov; V I Panfilov |
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Publication Detail:
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Type: Journal Article Date: 2007-07-23 |
Journal Detail:
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Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-02 Completed Date: 2008-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 2422-4 Citation Subset: IM |
Affiliation:
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Department of Medical Biology, Genetics and Ecology, Kursk State Medical University, Karl Marx Street 3, 305041 Kursk, Russia. polonikov@rambler.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Asthma / genetics* Case-Control Studies Female Genetic Predisposition to Disease* Genotype Glutamate-Cysteine Ligase / genetics* Glutathione / biosynthesis Humans Male Middle Aged Polymerase Chain Reaction Polymorphism, Single Nucleotide* Risk Factors |
| Chemical | |
Reg. No./Substance:
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70-18-8/Glutathione; EC 6.3.2.2/Glutamate-Cysteine Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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