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The relationship between plasma leptin and nutritional status in chronic hemodialysis patients.
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MedLine Citation:
PMID:  10576151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin serves an important role in suppressing appetite in mice and is known to be elevated in chronic renal failure (CRF) patients. But clinical significance of leptin as an appetite-reducing uremic toxin, remains to be determined. So we studied the relationship between plasma leptin and nutritional status in 46 chronic hemodialysis (HD) patients. Pre HD leptin was measured and divided by body mass index (BMI) to give adjusted leptin levels. KT/Vurea (K, dialyzer urea clearance; T, duration of HD; V, volume of distribution of urea), C-reactive protein (CRP), plasma insulin and nutritional parameters such as serum albumin, normalized protein catabolic rate (nPCR), subjective global assessment (SGA), BMI and mid-arm muscle circumference (MAMC) were also measured. Mean plasma leptin levels were 8.13+/-2.91 ng/mL (male 3.15+/-0.70; female 14.07+/-6.14, p<0.05). Adjusted leptin levels were positively correlated with nPCR (male r=0.47, p<0.05; female r=0.46, p<0.05), SGA (male r=0.43, p<0.05; female r=0.51, p<0.05) and MAMC (male r=0.60, p<0.005; female r=0.61, p<0.05). They did not correlate with KT/Vurea, serum albumin, hematocrit, bicarbonate, insulin and CRP. Presence of DM and erythropoietin therapy had no effect on leptin levels. These results suggest that leptin is a marker of good nutritional status rather than a cause of protein energy malnutrition in chronic HD patients.
Authors:
J R Koo; K Y Pak; K H Kim; R W Chun; H J Kim; D W Chae; M G Choi; J W Noh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  14     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Affiliation:
Department of Nephrology, College of Medicine, Hallym University, Chunchon, Korea. kjr@www.hallym.or.kr
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Cross-Sectional Studies
Female
Humans
Kidney Failure, Chronic / blood*,  complications,  therapy
Leptin / blood*
Male
Middle Aged
Nutrition Disorders / diagnosis,  etiology
Nutritional Status*
Obesity / etiology,  metabolism
Renal Dialysis* / adverse effects
Sex Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 10 Year: 1999
Volume: 14 Issue: 5
First Page: 546 Last Page: 551
ID: 3054459
PubMed Id: 10576151

The relationship between plasma leptin and nutritional status in chronic hemodialysis patients.
J. R. Koo Email: kjr@www.hallym.or.kr
K. Y. Pak
K. H. Kim
R. W. Chun
H. J. Kim
D. W. Chae
M. G. Choi
J. W. Noh
Department of Nephrology, College of Medicine, Hallym University, Chunchon, Korea.


Article Categories:
  • Research Article


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