Document Detail


The relationship between plasma apolipoprotein A-IV levels and coronary heart disease.
MedLine Citation:
PMID:  11780313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the relationship between plasma apoA-IV levels and coronary atherosclerosis and to explore its relation to other risk factors.
METHODS: Using ELISA techniques, plasma apoA-IV levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n = 118) and a control group (normal CAG, n = 63). The severity of atherosclerosis was assessed by stenosis scoring of the different lesions. Other parameters, including apoA-I, apoB, Lp(a), HDL-C, LDL-C, TG, and TC, were measured as well. Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-IV levels.
RESULTS: When compared with the control group, plasma apoA-IV levels were found to be lower in the CHD group. There was a weak negative correlation between plasma apoA-IV levels and the severity of coronary atherosclerosis. ApoA-IV was found to be a relatively independent risk factor for CHD. We also found a positive correlation between apoA-IV and triglyceride levels.
CONCLUSIONS: ApoA-IV may be important in the prediction of CHD and coronary atherosclerosis severity. It may also play an important role in the metabolism of triglycerides.
Authors:
M W Manpuya; J Guo; Y Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  114     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2002-01-08     Completed Date:  2002-02-13     Revised Date:  2013-10-23    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
Affiliation:
Third Hospital, Beijing University Medical School, Beijing 100083, China.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Analysis of Variance
Apolipoproteins / blood
Apolipoproteins A / blood*
Body Mass Index
Coronary Artery Disease / blood,  pathology
Coronary Disease / blood,  pathology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lipids / blood
Lipoproteins / blood
Logistic Models
Male
Middle Aged
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Apolipoproteins A; 0/Lipids; 0/Lipoproteins; 0/apolipoprotein A-IV

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