| The relationship between plasma apolipoprotein A-IV levels and coronary heart disease. | |
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MedLine Citation:
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PMID: 11780313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the relationship between plasma apoA-IV levels and coronary atherosclerosis and to explore its relation to other risk factors. METHODS: Using ELISA techniques, plasma apoA-IV levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n = 118) and a control group (normal CAG, n = 63). The severity of atherosclerosis was assessed by stenosis scoring of the different lesions. Other parameters, including apoA-I, apoB, Lp(a), HDL-C, LDL-C, TG, and TC, were measured as well. Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-IV levels. RESULTS: When compared with the control group, plasma apoA-IV levels were found to be lower in the CHD group. There was a weak negative correlation between plasma apoA-IV levels and the severity of coronary atherosclerosis. ApoA-IV was found to be a relatively independent risk factor for CHD. We also found a positive correlation between apoA-IV and triglyceride levels. CONCLUSIONS: ApoA-IV may be important in the prediction of CHD and coronary atherosclerosis severity. It may also play an important role in the metabolism of triglycerides. |
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Authors:
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M M Warner; J Guo; Y Zhao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 114 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2002-01-08 Completed Date: 2002-02-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Third Hospital, Beijing University Medical School, Beijing 100083, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Analysis of Variance Apolipoproteins / blood Apolipoproteins A / blood* Body Mass Index Coronary Artery Disease / blood, pathology Coronary Disease / blood, pathology* Enzyme-Linked Immunosorbent Assay Female Humans Lipids / blood Lipoproteins / blood Logistic Models Male Middle Aged Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Apolipoproteins A; 0/Lipids; 0/Lipoproteins; 0/apolipoprotein A-IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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