Document Detail


The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas.
MedLine Citation:
PMID:  15662977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the radiological and histological features of, and the influences of the expression of VEGF and its two major receptors, Flt-1 and Flk-1, on the development of peritumoral brain edema (PTBE) in patients with intracranial meningiomas. The expressions of VEGF and VEGF receptors in the immunohistochemical study were analyzed in relation to several factors, including tumor size, location, vascularity, and blood supply, as seen on digital subtraction angiographic studies. The edema volume (P = 0.0003) and edema index (P < 0.0001) had a significantly positive relation to VEGF expression. The positivity of Flt-1 and Flk-1 was mainly observed in tumor vessels; 44 cases (37.2%) were positive for the Flt-1 antibody and 37 cases (31.4%) for the Flk-1 antibody. The mean value of the edema index of the positive-Flt-1 group (5.220 +/- 11.586) was significantly higher than that of the negative-Flt-1 group (1.782 +/- 2.559) (P < 0.0001). The mean value of the edema index of the positive-Flk-1 group (3.925 +/- 5.870) was slightly higher than that of the negative-Flk-1 group (2.671 +/- 8.136) (P < 0.0001). Our data suggest that the expressions of VEGF and VEGF receptors positively relate to each other and to the formation of PTBE in patients with meningiomas.
Authors:
Shinji Otsuka; Takashi Tamiya; Yasuhiro Ono; Hiroyuki Michiue; Kazuhiko Kurozumi; Shigeru Daido; Hirokazu Kambara; Isao Date; Takashi Ohmoto
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  70     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-03-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brain Edema / etiology,  metabolism*
Female
History, 17th Century
Humans
Immunohistochemistry
Male
Meningeal Neoplasms / complications,  metabolism*,  pathology
Meningioma / complications,  metabolism*,  pathology
Receptors, Vascular Endothelial Growth Factor / biosynthesis*
Retrospective Studies
Vascular Endothelial Growth Factor A / biosynthesis*
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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