| The relationship between perfusion medium flow rate and steroid secretion in the isolated perfused rat adrenal gland in situ. | |
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MedLine Citation:
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PMID: 3805967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the in-situ, isolated, perfused rat adrenal preparation, we have investigated the effects of changes in the rate of perfusate flow through the gland, brought about both mechanically and by the use of vasoactive agents, in the absence of known adrenocortical stimulants. Adenosine caused a significant increase in the rate of perfusate flow through the adrenal, with a concomitant rise in corticosterone, but not aldosterone, secretion. Adrenaline, on the other hand, caused a decrease in the rate of perfusate flow through the gland, accompanied by a decrease in the rate of steroid secretion. Furthermore, increases in the rate of delivery of perfusate to the gland, brought about by increasing the peristaltic pump rate, caused a large increase in corticosterone secretion, although aldosterone was unaffected. Neither adenosine nor a mechanically increased rate of perfusate delivery increased steroid secretion by collagenase-dispersed rat adrenocortical cells superfused on a Sephadex column. These results suggest the existence of hitherto unsuspected intraglandular mechanisms for the control of steroid secretion. |
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Authors:
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J P Hinson; G P Vinson; B J Whitehouse |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of endocrinology Volume: 111 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-03-05 Completed Date: 1987-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Adrenal Glands / drug effects*, physiology Aldosterone / secretion* Animals Corticosterone / secretion* Epinephrine / pharmacology* Perfusion Rats Rheology |
| Chemical | |
Reg. No./Substance:
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50-22-6/Corticosterone; 51-43-4/Epinephrine; 52-39-1/Aldosterone; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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