Document Detail

The relationship between particle deposition in the anterior nasal passage and nasal passage characteristics.
MedLine Citation:
PMID:  10947320     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to examine the effects of nasal passage characteristics on anterior particle deposition during cyclical breathing. Forty healthy, nonsmoking, adult subjects participated in this study. Nasal passage characteristics such as nostril length, width, angle, ellipticity, and minimum nasal cross-sectional area were measured. The subjects inhaled a polydisperse radioactively tagged aerosol (mass median aerodynamic diameter = 5.4 microns, geometric standard deviation [GSD] = 1.3) into the nose and exhaled through the mouth. The amount of radioactivity in the nose was measured immediately after inhalation and thereafter for 54 minutes. At 52.5 minutes, subjects wiped the accessible portion of the anterior nose to remove any remaining activity. The difference in activity at 52 and 54 minutes was used as a measure of activity removed during the nose wipe. Percentage of activity in the nasal passage at 52 minutes and percentage of activity removed with the nose wipe were considered surrogates for particles deposited in the anterior nasal passage. A multiple regression analysis showed that the degree of ellipticity of the nostrils was significantly related to particle deposition in the anterior nasal passage. These results suggest that ellipticity of the nostrils may be a determinant of the amount of particle deposition in the anterior nasal passage.
J Kesavan; R Bascom; B Laube; D L Swift
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  13     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  T    
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA.
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MeSH Terms
Nasal Cavity / anatomy & histology,  metabolism*
Nebulizers and Vaporizers*
Particle Size
Regression Analysis
Technetium Tc 99m Sulfur Colloid / diagnostic use
Reg. No./Substance:
0/Aerosols; 0/Technetium Tc 99m Sulfur Colloid

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