| The relationship between particle deposition in the anterior nasal passage and nasal passage characteristics. | |
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MedLine Citation:
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PMID: 10947320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to examine the effects of nasal passage characteristics on anterior particle deposition during cyclical breathing. Forty healthy, nonsmoking, adult subjects participated in this study. Nasal passage characteristics such as nostril length, width, angle, ellipticity, and minimum nasal cross-sectional area were measured. The subjects inhaled a polydisperse radioactively tagged aerosol (mass median aerodynamic diameter = 5.4 microns, geometric standard deviation [GSD] = 1.3) into the nose and exhaled through the mouth. The amount of radioactivity in the nose was measured immediately after inhalation and thereafter for 54 minutes. At 52.5 minutes, subjects wiped the accessible portion of the anterior nose to remove any remaining activity. The difference in activity at 52 and 54 minutes was used as a measure of activity removed during the nose wipe. Percentage of activity in the nasal passage at 52 minutes and percentage of activity removed with the nose wipe were considered surrogates for particles deposited in the anterior nasal passage. A multiple regression analysis showed that the degree of ellipticity of the nostrils was significantly related to particle deposition in the anterior nasal passage. These results suggest that ellipticity of the nostrils may be a determinant of the amount of particle deposition in the anterior nasal passage. |
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Authors:
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J Kesavan; R Bascom; B Laube; D L Swift |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Volume: 13 ISSN: 0894-2684 ISO Abbreviation: J Aerosol Med Publication Date: 2000 |
Date Detail:
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Created Date: 2000-07-13 Completed Date: 2000-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8809251 Medline TA: J Aerosol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-23 Citation Subset: T |
Affiliation:
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Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA. kesavan@welch.jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aerosols* Female Humans Male Nasal Cavity / anatomy & histology, metabolism* Nebulizers and Vaporizers* Particle Size Regression Analysis Technetium Tc 99m Sulfur Colloid / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Technetium Tc 99m Sulfur Colloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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