Document Detail

The relationship between ovarian steroids and uterine estrogen receptors during late pregnancy.
MedLine Citation:
PMID:  2072817     Owner:  NLM     Status:  MEDLINE    
Although a direct interdependence exists between the ovarian steroids, estrogen and progesterone, the exact role of these two hormones during pregnancy, especially late pregnancy, is not completely understood. Investigations have been conducted to determine whether the circulating levels of progesterone and estrogen or changes in the ratio of progesterone/estrogen in relation to the concentration of uterine estrogen receptors are associated with triggering parturition. Ninety-day old female rats were sacrificed at gestation days 14, 16, 18, 20 and two days post-partum. The plasma levels of estradiol and progesterone were measured by solid-phase radioimmunoassay. Uterine cytosol was subjected to a charcoal binding assay to determine the concentration of estrogen receptors. Our findings demonstrate that there is a significant (p less than 0.05) drop in both plasma progesterone and estradiol during late pregnancy. Also indicated is a significant (p less than 0.05) increase in uterine estrogen receptors throughout late pregnancy. Finally, during this period there is a direct correlation between the shift in the progesterone/estrogen ratio and the increase in the concentration of uterine estrogen receptors in late pregnancy.
T M Cathey; K W Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  49     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-20     Completed Date:  1991-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
Department of Anatomical Sciences, University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City 73190.
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MeSH Terms
Estradiol / blood*
Pregnancy, Animal / metabolism*
Progesterone / blood*
Receptors, Estrogen / metabolism*
Receptors, Progesterone / metabolism*
Time Factors
Uterus / metabolism*
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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