Document Detail

The relationship between nutrition and circadian rhythms in mammals.
MedLine Citation:
PMID:  17451793     Owner:  NLM     Status:  MEDLINE    
The master clock located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus regulates circadian rhythms in mammals. The clock is an intracellular, transcriptional mechanism sharing the same molecular components in SCN neurons and in peripheral cells, such as the liver, intestine, and retina. The circadian clock controls food processing and energy homeostasis by regulating the expression and/or activity of enzymes involved in cholesterol, amino acid, lipid, glycogen, and glucose metabolism. In addition, many hormones involved in metabolism, such as insulin, glucagon, adiponectin, corticosterone, leptin, and ghrelin, exhibit circadian oscillation. Furthermore, disruption of circadian rhythms is involved in the development of cancer, metabolic syndrome, and obesity. Metabolism and food intake also feed back to influence the biological clock. Calorie restriction (CR) entrains the SCN clock, whereas timed meals entrain peripheral oscillators. Furthermore, the cellular redox state, dictated by food metabolism, and several nutrients, such as glucose, ethanol, adenosine, caffeine, thiamine, and retinoic acid, can phase-shift circadian rhythms. In conclusion, there is a large body of evidence that links feeding regimens, food components, and the biological clock.
Oren Froy
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-03-24
Journal Detail:
Title:  Frontiers in neuroendocrinology     Volume:  28     ISSN:  0091-3022     ISO Abbreviation:  Front Neuroendocrinol     Publication Date:    2007 Aug-Sep
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513292     Medline TA:  Front Neuroendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-71     Citation Subset:  IM    
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
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MeSH Terms
Biological Clocks / physiology*
Caloric Restriction
Circadian Rhythm / physiology*
Energy Metabolism
Feeding Behavior
Nutritional Status*

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