Document Detail


The relationship between nighttime dipping in blood pressure and cerebral hemodynamics in nonstroke patients.
MedLine Citation:
PMID:  18046099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inadequate dipping in nighttime blood pressure (BP) is associated with cerebrovascular disease. The authors aimed to determine whether inadequate nocturnal dipping was associated with abnormalities in cerebrovascular hemodynamics in individuals without stroke. Participants in this study underwent 24-hour ambulatory BP monitoring followed by morning transcranial Doppler measurements of blood flow velocities (BFVs) in the middle cerebral artery during supine rest, head-up tilt, hypocapnia, and hypercapnia. Nighttime BP decline by <10% was considered nondipping. Of the 102 nonstroke participants (mean age, 53.6 years), 35 (34%) were dippers. Although nondippers had similar BFV and cerebrovascular resistance (CVR) while supine, they had a lower BFV (P=.04) and greater CVR (P=.02) during head-up tilt compared with dippers. Moreover, greater nighttime dipping in both systolic BP (P=.006) and diastolic BP (P=.03) were associated with higher daytime BFV and lower CVR (P=.01 for systolic BP; P=.02 for diastolic BP). Inadequate nocturnal BP dipping is associated with lower daytime cerebral blood flow, especially during head-up tilt.
Authors:
Ihab Hajjar; Magdy Selim; Peter Novak; Vera Novak
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  9     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-29     Completed Date:  2008-04-08     Revised Date:  2011-11-21    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-36     Citation Subset:  IM    
Affiliation:
Beth Israel Deaconess Medical Center, Institute for Aging Research at Hebrew SeniorLife, Boston, MA 02131, USA. ihabhajjar@hrca.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Cerebrovascular Circulation / physiology*
Circadian Rhythm / physiology*
Female
Hemodynamics / physiology*
Humans
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
1R01-NS045745-01A2/NS/NINDS NIH HHS; 2P60 AG08812/AG/NIA NIH HHS; M01-RR01302/RR/NCRR NIH HHS; R01 NS045745-03/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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