| The relationship between nighttime dipping in blood pressure and cerebral hemodynamics in nonstroke patients. | |
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MedLine Citation:
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PMID: 18046099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inadequate dipping in nighttime blood pressure (BP) is associated with cerebrovascular disease. The authors aimed to determine whether inadequate nocturnal dipping was associated with abnormalities in cerebrovascular hemodynamics in individuals without stroke. Participants in this study underwent 24-hour ambulatory BP monitoring followed by morning transcranial Doppler measurements of blood flow velocities (BFVs) in the middle cerebral artery during supine rest, head-up tilt, hypocapnia, and hypercapnia. Nighttime BP decline by <10% was considered nondipping. Of the 102 nonstroke participants (mean age, 53.6 years), 35 (34%) were dippers. Although nondippers had similar BFV and cerebrovascular resistance (CVR) while supine, they had a lower BFV (P=.04) and greater CVR (P=.02) during head-up tilt compared with dippers. Moreover, greater nighttime dipping in both systolic BP (P=.006) and diastolic BP (P=.03) were associated with higher daytime BFV and lower CVR (P=.01 for systolic BP; P=.02 for diastolic BP). Inadequate nocturnal BP dipping is associated with lower daytime cerebral blood flow, especially during head-up tilt. |
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Authors:
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Ihab Hajjar; Magdy Selim; Peter Novak; Vera Novak |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 9 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-29 Completed Date: 2008-04-08 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 929-36 Citation Subset: IM |
Affiliation:
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Beth Israel Deaconess Medical Center, Institute for Aging Research at Hebrew SeniorLife, Boston, MA 02131, USA. ihabhajjar@hrca.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* Cerebrovascular Circulation / physiology* Circadian Rhythm / physiology* Female Hemodynamics / physiology* Humans Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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1R01-NS045745-01A2/NS/NINDS NIH HHS; 2P60 AG08812/AG/NIA NIH HHS; M01-RR01302/RR/NCRR NIH HHS; R01 NS045745-03/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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