Document Detail

The relationship between new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.
MedLine Citation:
PMID:  10394138     Owner:  NLM     Status:  MEDLINE    
Creutzfeldt-Jakob disease (CJD) has been transmitted in the laboratory and also by iatrogenic accident. However, research has failed to find evidence that its most common form (sporadic CJD) is a natural infection and, in particular, that there is a causal link with scrapie. Bovine spongiform encephalopathy (BSE) probably resulted from scrapie infection in cattle food. In the wake of the BSE epidemic, a novel clinico-pathological form of CJD has been recognized: new variant CJD (nvCJD). This paper reviews the relationship between nvCJD and BSE and presents the accumulated evidence supporting the view that nvCJD resulted from BSE contamination of human food.
R Knight
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vox sanguinis     Volume:  76     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-17     Completed Date:  1999-08-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
National CJD Surveillance Unit, Western General Hospital, and Department of Clinical Neuroscience, University of Edinburgh, UK.
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MeSH Terms
Creutzfeldt-Jakob Syndrome / etiology*,  genetics*
Encephalopathy, Bovine Spongiform / complications*,  transmission*
Genetic Variation

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