Document Detail


The relationship between new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.
MedLine Citation:
PMID:  10394138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Creutzfeldt-Jakob disease (CJD) has been transmitted in the laboratory and also by iatrogenic accident. However, research has failed to find evidence that its most common form (sporadic CJD) is a natural infection and, in particular, that there is a causal link with scrapie. Bovine spongiform encephalopathy (BSE) probably resulted from scrapie infection in cattle food. In the wake of the BSE epidemic, a novel clinico-pathological form of CJD has been recognized: new variant CJD (nvCJD). This paper reviews the relationship between nvCJD and BSE and presents the accumulated evidence supporting the view that nvCJD resulted from BSE contamination of human food.
Authors:
R Knight
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vox sanguinis     Volume:  76     ISSN:  0042-9007     ISO Abbreviation:  Vox Sang.     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-17     Completed Date:  1999-08-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
Affiliation:
National CJD Surveillance Unit, Western General Hospital, and Department of Clinical Neuroscience, University of Edinburgh, UK. R.Knight@ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Creutzfeldt-Jakob Syndrome / etiology*,  genetics*
Encephalopathy, Bovine Spongiform / complications*,  transmission*
Genetic Variation
Humans

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