Document Detail

The relationship between neonatal developmental dysplasia of the hip and maternal hyperthyroidism.
MedLine Citation:
PMID:  18520279     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Development of the hip joint is complete by 11 weeks of gestation. As triiodothyronine and thyroxine are important regulators of early bone and muscle development, we hypothesized that excessive thyroid hormone in the early fetal period was a congenital risk factor of developmental dysplasia of the hip (DDH). Consequently, it was proposed that elevations of maternal thyroxine in the first trimester could alter the incidence of neonatal DDH. METHODS: The patient population comprised a retrospective cohort of all children born in Yukiguni-Yamato General Hospital from 1996 to 2003 (n = 2137). All infants were physically assessed for DDH. Pregnancies were divided into normal, Graves disease (n = 15), and severe hyperemesis gravidarum in the first trimester (n = 39, which is associated with gestational transient hyperthyroidism in up to 73%). RESULTS: From a total 2137 pregnancies, 21 children (18 female) were diagnosed with DDH. Thirteen affected infants were from normal pregnancies (0.63%), 3 from mothers affected with Graves disease (20%, P < 0.0001), and 5 from mothers with hyperemesis gravidarum (12.8%, P < 0.0001). CONCLUSIONS: Developmental dysplasia of the hip is associated with first-trimester maternal hyperthyroidism, and infants of these mothers should be closely checked for hip abnormalities.
Norio Ishikawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric orthopedics     Volume:  28     ISSN:  0271-6798     ISO Abbreviation:  J Pediatr Orthop     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109053     Medline TA:  J Pediatr Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-4     Citation Subset:  IM    
Department of Pediatrics, Yukiguni-Yamato General Hospital, Niigata, Japan.
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MeSH Terms
Biological Markers / blood
Follow-Up Studies
Graves Disease / blood,  complications*,  epidemiology
Hip Dislocation, Congenital / blood,  epidemiology,  etiology*
Infant, Newborn
Japan / epidemiology
Pregnancy Complications*
Retrospective Studies
Risk Factors
Severity of Illness Index
Thyrotropin / blood
Thyroxine / blood
Reg. No./Substance:
0/Biological Markers; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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