Document Detail

Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns.
MedLine Citation:
PMID:  20921924     Owner:  NLM     Status:  MEDLINE    
Amniotic fluid infection with chorioamnionitis is associated with increased risks of morbidity and mortality in children born prematurely. These risks depend on the presence of a fetal inflammatory response. We measured the concentrations of 25 proteins in the blood of 871 infants born before the 28th wk of gestation and examined their placentas for acute inflammation. Newborns who had inflammatory lesions of the placenta were much more likely than their peers (p < 0.01) to have elevated blood concentrations of cytokines (IL-1β, IL-6, and TNF-α), chemokines (IL-8, MIP-1β, RANTES, and I-TAC), adhesion molecules (ICAM-1, ICAM-3, and E-selectin), matrix metalloproteinases (MMP-1 and MMP-9), the angiogenic inflammatory factor VEGF and its receptor VEGF-R2, and acute phase proteins (SAA and CRP) during the first 3 d after birth. In contrast, newborns with poor placental perfusion had lower levels of inflammatory proteins (p < 0.01; IL-6, RANTES, ICAM-1, ICAM-3, VCAM-1, E-selectin, MMP-1, MMP-9, MPO, and VEGF). An inverse pattern was found between newborn levels of VEGF and its competitive inhibitor VEGF-R1 in both the inflamed and poorly perfused placenta categories. These results confirm the predictive value of placental histology for the presence or absence of elevated inflammatory response in newborns.
Jonathan L Hecht; Raina N Fichorova; Vanessa F Tang; Elizabeth N Allred; Thomas F McElrath; Alan Leviton;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-29     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / metabolism,  microbiology*
Blood Proteins / analysis*
Cell Adhesion Molecules / blood
Chemokines / blood
Chorioamnionitis / blood,  pathology*
Cytokines / blood
Infant, Newborn
Infant, Premature / blood*
Matrix Metalloproteinases / blood
Placenta / metabolism,  pathology*
Receptors, Vascular Endothelial Growth Factor / blood
Vascular Endothelial Growth Factor A / blood
Grant Support
5P30HD018655-28/HD/NICHD NIH HHS; 5U01NS040069-05/NS/NINDS NIH HHS; P30 HD018655/HD/NICHD NIH HHS; P30 HD018655-28/HD/NICHD NIH HHS; U01 NS040069/NS/NINDS NIH HHS; U01 NS040069-05/NS/NINDS NIH HHS
Reg. No./Substance:
0/Blood Proteins; 0/Cell Adhesion Molecules; 0/Chemokines; 0/Cytokines; 0/Vascular Endothelial Growth Factor A; EC, Vascular Endothelial Growth Factor; EC 3.4.24.-/Matrix Metalloproteinases

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