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The relationship between the myocardial T2* value and left ventricular volumetric and functional parameters in thalassemia major patients.
MedLine Citation:
PMID:  21647857     Owner:  NLM     Status:  Publisher    
PURPOSE: Cardiac involvement in thalassemia major (TM) is mainly characterized by left ventricular dysfunction caused by iron overload. Cardiovascular magnetic resonance (CMR) imaging including myocardial T2* measurement is becoming increasingly popular for quantitatively evaluating myocardial iron overload. The aim of this study was to evaluate the relationship between the myocardial T2* value and left ventricular functional parameters and to examine the associations between the degree of cardiac iron load and various clinical parameters. MATERIALS AND METHODS: A retrospective analysis of 47 patients (25 males and 22 females, mean age, 23.0±5.4 years) with TM was performed. Myocardial iron load was assessed by T2* measurements, and volumetric functions were analyzed using the Steady State Free Precession (SSFP) sequence. RESULTS: In patients with myocardial iron deposition (T2* < 20 ms), the mean LVEF was 64,73±4,94%. The left ventricular ejection fraction (LVEF) of patients with myocardial siderosis was significantly lower than that of patients without myocardial siderosis (r = 0.35, P = 0.014). Inverse and significant correlations between both the LV end-systolic volume index and the left ventricular (LV) end-diastolic volume index and the myocardial T2* value (r = -0.32, P = 0.027 and r = -0.29, P = 0.046 respectively) were observed. There was an inverse correlation between the myocardial T2* value and the LIC (r = -0.31, P = 0.037). Cardiac T2* was not associated with serum ferritin levels, pre-transfusion hemoglobin levels or the annual red cell consumption rate. CONCLUSION: Myocardial iron load assessed by cardiac MRI (T2*) is associated with deterioration in left ventricular function. Thalassemia major patients with myocardial siderosis may have LVEF values within normal limits, but this result must be interpreted cautiously.
Selen Bayraktaroglu; Yesim Aydinok; Dilek Yildiz; Hatice Uluer; Recep Savas; Alper Hudaver
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-06
Journal Detail:
Title:  Diagnostic and interventional radiology (Ankara, Turkey)     Volume:  -     ISSN:  1305-3612     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241152     Medline TA:  Diagn Interv Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Radiology, Ege University School of Medicine, İzmir, Turkey.
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