| The relationship between the myocardial T2* value and left ventricular volumetric and functional parameters in thalassemia major patients. | |
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MedLine Citation:
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PMID: 21647857 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Cardiac involvement in thalassemia major (TM) is mainly characterized by left ventricular dysfunction caused by iron overload. Cardiovascular magnetic resonance (CMR) imaging including myocardial T2* measurement is becoming increasingly popular for quantitatively evaluating myocardial iron overload. The aim of this study was to evaluate the relationship between the myocardial T2* value and left ventricular functional parameters and to examine the associations between the degree of cardiac iron load and various clinical parameters. MATERIALS AND METHODS: A retrospective analysis of 47 patients (25 males and 22 females, mean age, 23.0±5.4 years) with TM was performed. Myocardial iron load was assessed by T2* measurements, and volumetric functions were analyzed using the Steady State Free Precession (SSFP) sequence. RESULTS: In patients with myocardial iron deposition (T2* < 20 ms), the mean LVEF was 64,73±4,94%. The left ventricular ejection fraction (LVEF) of patients with myocardial siderosis was significantly lower than that of patients without myocardial siderosis (r = 0.35, P = 0.014). Inverse and significant correlations between both the LV end-systolic volume index and the left ventricular (LV) end-diastolic volume index and the myocardial T2* value (r = -0.32, P = 0.027 and r = -0.29, P = 0.046 respectively) were observed. There was an inverse correlation between the myocardial T2* value and the LIC (r = -0.31, P = 0.037). Cardiac T2* was not associated with serum ferritin levels, pre-transfusion hemoglobin levels or the annual red cell consumption rate. CONCLUSION: Myocardial iron load assessed by cardiac MRI (T2*) is associated with deterioration in left ventricular function. Thalassemia major patients with myocardial siderosis may have LVEF values within normal limits, but this result must be interpreted cautiously. |
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Authors:
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Selen Bayraktaroglu; Yesim Aydinok; Dilek Yildiz; Hatice Uluer; Recep Savas; Alper Hudaver |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-06 |
Journal Detail:
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Title: Diagnostic and interventional radiology (Ankara, Turkey) Volume: - ISSN: 1305-3612 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241152 Medline TA: Diagn Interv Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Ege University School of Medicine, İzmir, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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