| The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 11511786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using immunohistochemical staining, we studied the relationship between the microvessel count (MC) and the expression of K-ras, mutant p53 protein, and vascular endothelial growth factor (VEGF) in 61 surgically resected non-small cell lung cancers (NSCLC) (42 squamous cell carcinoma, 14 adenocarcinoma, 2 large cell carcinoma, 2 adenosquamous carcinoma, and 1 mucoepidermoid carcinoma). MC of the tumors with lymph node (LN) metastasis was significantly higher than that of tumors without LN metastasis (66.1+/-23.1 vs. 33.8+/-13.1, p<0.05). VEGF was positive in 54 patients (88.5%). MC was 58.1+/-25.2 (mean+/-S.D.) in a x200 field, and it was significantly higher in VEGF(+) tumors than in VEGF(-) tumors (61.4+/-23.7 vs. 32.9+/-23.8, p<0.05). VEGF expression was higher in K-ras-positive or mutant p53-positive tumors than in negative tumors (p<0.05). MC was significantly higher in K-ras(+) tumors than in K-ras(-) tumors, although it did not differ according to the level of mutant p53 protein expression. Survival did not differ with VEGF, mutant p53, or K-ras expression, or the level of MC. In conclusion, there is a flow of molecular alterations from K-ras and p53, to VEGF expression, leading to angiogenesis and ultimately lymph node metastasis. Correlations between variables in close approximation and the lack of prognostic significance of individual molecular alterations suggest that tumorigenesis and metastasis are multifactorial processes. |
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Authors:
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Y H Kang; K S Kim; Y K Yu; S C Lim; Y C Kim; K O Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Korean medical science Volume: 16 ISSN: 1011-8934 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-20 Completed Date: 2001-10-25 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 417-23 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Chonnam National University Medical School, Research Institute of Medical Science, Kwangju, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Non-Small-Cell Lung / blood supply*, chemistry, mortality Endothelial Growth Factors / analysis* Female Humans Lung Neoplasms / blood supply*, chemistry, mortality Lymphokines / analysis* Male Middle Aged Neovascularization, Pathologic / metabolism* Survival Rate Tumor Suppressor Protein p53 / analysis* Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors ras Proteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Lymphokines; 0/Tumor Suppressor Protein p53; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC 3.6.5.2/ras Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Korean Med Sci Journal ID (pmc): jkms ISSN: 1011-8934 ISSN: 1598-6357 Publisher: Korean Academy of Medical Sciences |
Article Information Download PDF  Print publication date: Month: 8 Year: 2001 Volume: 16 Issue: 4 First Page: 417 Last Page: 423 ID: 3054778 PubMed Id: 11511786 Publisher Item Identifier: 200108417 |
| The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer. | |
| Y. H. Kang | |
| K. S. Kim | |
| Y. K. Yu | |
| S. C. Lim | |
| Y. C. Kim | |
| K. O. Park | |
| Department of Internal Medicine, Chonnam National University Medical School, Research Institute of Medical Science, Kwangju, Korea. |
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