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The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
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MedLine Citation:
PMID:  11511786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunohistochemical staining, we studied the relationship between the microvessel count (MC) and the expression of K-ras, mutant p53 protein, and vascular endothelial growth factor (VEGF) in 61 surgically resected non-small cell lung cancers (NSCLC) (42 squamous cell carcinoma, 14 adenocarcinoma, 2 large cell carcinoma, 2 adenosquamous carcinoma, and 1 mucoepidermoid carcinoma). MC of the tumors with lymph node (LN) metastasis was significantly higher than that of tumors without LN metastasis (66.1+/-23.1 vs. 33.8+/-13.1, p<0.05). VEGF was positive in 54 patients (88.5%). MC was 58.1+/-25.2 (mean+/-S.D.) in a x200 field, and it was significantly higher in VEGF(+) tumors than in VEGF(-) tumors (61.4+/-23.7 vs. 32.9+/-23.8, p<0.05). VEGF expression was higher in K-ras-positive or mutant p53-positive tumors than in negative tumors (p<0.05). MC was significantly higher in K-ras(+) tumors than in K-ras(-) tumors, although it did not differ according to the level of mutant p53 protein expression. Survival did not differ with VEGF, mutant p53, or K-ras expression, or the level of MC. In conclusion, there is a flow of molecular alterations from K-ras and p53, to VEGF expression, leading to angiogenesis and ultimately lymph node metastasis. Correlations between variables in close approximation and the lack of prognostic significance of individual molecular alterations suggest that tumorigenesis and metastasis are multifactorial processes.
Authors:
Y H Kang; K S Kim; Y K Yu; S C Lim; Y C Kim; K O Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  16     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2001-10-25     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Chonnam National University Medical School, Research Institute of Medical Science, Kwangju, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Non-Small-Cell Lung / blood supply*,  chemistry,  mortality
Endothelial Growth Factors / analysis*
Female
Humans
Lung Neoplasms / blood supply*,  chemistry,  mortality
Lymphokines / analysis*
Male
Middle Aged
Neovascularization, Pathologic / metabolism*
Survival Rate
Tumor Suppressor Protein p53 / analysis*
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
ras Proteins / analysis*
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Lymphokines; 0/Tumor Suppressor Protein p53; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC 3.6.5.2/ras Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 8 Year: 2001
Volume: 16 Issue: 4
First Page: 417 Last Page: 423
ID: 3054778
PubMed Id: 11511786
Publisher Item Identifier: 200108417

The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Y. H. Kang
K. S. Kim
Y. K. Yu
S. C. Lim
Y. C. Kim
K. O. Park
Department of Internal Medicine, Chonnam National University Medical School, Research Institute of Medical Science, Kwangju, Korea.


Article Categories:
  • Research Article


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