Document Detail


The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism.
MedLine Citation:
PMID:  9500479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Data on fetal blood homocyst(e)ine concentrations are not available. We tested the hypothesis that homocyst(e)ine crosses the maternal/placental/fetal interphases and is sequestered by the fetus. STUDY DESIGN: The concentration of homocyst(e)ine was determined at parturition in peripheral venous plasma from 35 nulliparous healthy pregnant women and umbilical arterial and venous plasma from their conceptus. RESULTS: Findings demonstrated a descending concentration gradient of plasma homocyst(e)ine from maternal vein to umbilical vein and to umbilical artery; the decrease at each interphase approximated 1 micromol/L. The neonate weight and gestational age were inversely related to maternal homocyst(e)ine concentrations. CONCLUSION: The umbilical vein to umbilical artery homocyst(e)ine decrement suggests that uptake of homocyst(e)ine occurs in the fetus. The likely incorporation of homocyst(e)ine into the fetal metabolic cycle may implicate maternal homocyst(e)ine as having a potential nutritional role in the fetus. Further studies are required to explain the role of homocyst(e)ine in fetal metabolism and development.
Authors:
M R Malinow; A Rajkovic; P B Duell; D L Hess; B M Upson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  178     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  AIM; IM    
Affiliation:
Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton 97006-3448, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetal Blood / metabolism*
Folic Acid / blood
Homocysteine / blood*
Homocystine / blood*
Humans
Infant, Newborn
Labor, Obstetric
Maternal-Fetal Exchange*
Pregnancy
Reference Values
Umbilical Arteries
Umbilical Veins
Grant Support
ID/Acronym/Agency:
GCRC RR080/RR/NCRR NIH HHS; P5I RROO163/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
454-28-4/Homocysteine; 462-10-2/Homocystine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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