Document Detail

The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood.
MedLine Citation:
PMID:  21923665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND:   Dietary changes may epigenetically modify fetal gene expression during critical periods of development to potentially influence disease susceptibility. This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes.
METHODS:   Pregnant women (n=628) were recruited in the last trimester of pregnancy. Folate status determined by both food frequency questionnaires and folate levels in maternal and cord blood serum was examined in relation to infant allergic outcomes at 1 year of age (n=484).
RESULTS:   Infants who developed allergic disease (namely eczema) did not show any differences in cord blood or maternal folate levels compared with children without disease. Although maternal folate intake from foods was also not different, folate derived from supplements was higher (P=0.017) in children with subsequent eczema. Furthermore, infants exposed to >500 μg folic acid/day as a supplement in utero were more likely to develop eczema than those taking <200 μg/day (OR [odds ratio] =1.85; 95% CI 1.14-3.02; P=0.013), remaining significant after adjustment for maternal allergy and other confounders. There was a nonlinear relationship between cord blood folate and sensitization, with folate levels <50 nmol/l (OR=3.02; 95% CI 1.16-7.87; P=0.024) and >75 nmol/l (OR=3.59; 95% CI 1.40-9.20; P=0.008) associated with greater sensitization risk than levels between 50 and 75 nmol/l.
CONCLUSION:   Fetal levels between 50 and 75 nmol/l appeared optimal for minimizing sensitization. While folate taken as a supplement in higher doses during the third trimester was associated with eczema, there was no effect on other allergic outcomes including sensitization. Further studies are needed to determine the significance of this.
J A Dunstan; C West; S McCarthy; J Metcalfe; S Meldrum; W H Oddy; M K Tulic; N D'Vaz; S L Prescott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-19
Journal Detail:
Title:  Allergy     Volume:  67     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-03-28     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  50-7     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Dietary Supplements / adverse effects
Fetal Blood / chemistry*
Folic Acid / blood*
Hypersensitivity / etiology*
Infant, Newborn
Pregnancy / blood*
Prenatal Exposure Delayed Effects / blood*
Reg. No./Substance:
935E97BOY8/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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