Document Detail


The relationship between maternal body mass, smoking status and ethnicity and first trimester nuchal translucency thickness.
MedLine Citation:
PMID:  21351280     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the existence of a relationship between maternal body mass, maternal ethnicity and maternal smoking status and nuchal translucency (NT) in the first trimester of pregnancy. METHODS: NT measurements from 130 339 euploid, singleton pregnancies were converted to NT multiples of the median (MoM) and delta NT using expected medians determined using regression analysis. Relationships between maternal body mass index (BMI), maternal weight, maternal ethnicity and maternal smoking status and NT MoM and delta NT were examined. RESULTS: NT increased with gestational age. Uncorrected NT MoM and delta NT demonstrated small but significant positive relationships with either maternal BMI or maternal weight. Both NT MoM and delta NT were slightly, but significantly, increased in smokers compared to non-smokers and Afro-Caribbean compared to Caucasians, and slightly, but significantly, decreased in Asians compared to Caucasians. CONCLUSION: Although statistically significant, all the changes reported are likely to be too small to be relevant in terms of correcting in prenatal screening. Copyright © 2011 John Wiley & Sons, Ltd.
Authors:
Nicholas J Cowans; Kevin Spencer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-24
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation:
Prenatal Screening Unit, Clinical Biochemistry Department, King George Hospital, Goodmayes, UK.
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