Document Detail


The relationship between maternal adiposity and infant weight gain, and childhood wheeze and atopy.
MedLine Citation:
PMID:  23291350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Obesity and asthma have increased in westernised countries. Maternal obesity may increase childhood asthma risk. If this relation is causal, it may be mediated through factors associated with maternal adiposity, such as fetal development, pregnancy complications or infant adiposity. We investigated the relationships of maternal body mass index (BMI) and fat mass with childhood wheeze, and examined the influences of infant weight gain and childhood obesity.
METHODS: Maternal prepregnancy BMI and estimated fat mass (from skinfold thicknesses) were related to asthma, wheeze and atopy in 940 children. Transient or persistent/late wheeze was classified using questionnaire data collected at ages 6, 12, 24 and 36 months and 6 years. At 6 years, skin-prick testing was conducted and exhaled nitric oxide and spirometry measured. Infant adiposity gain was calculated from skinfold thickness at birth and 6 months.
RESULTS: Greater maternal BMI and fat mass were associated with increased childhood wheeze (relative risk (RR) 1.08 per 5 kg/m(2), p=0.006; RR 1.09 per 10 kg, p=0.003); these reflected associations with transient wheeze (RR 1.11, p=0.003; RR 1.13, p=0.002, respectively), but not with persistent wheeze or asthma. Infant adiposity gain was associated with persistent wheeze, but not significantly. Adjusting for infant adiposity gain or BMI at 3 or 6 years did not reduce the association between maternal adiposity and transient wheeze. Maternal adiposity was not associated with offspring atopy, exhaled nitric oxide, or spirometry.
DISCUSSION: Greater maternal adiposity is associated with transient wheeze but not asthma or atopy, suggesting effects upon airway structure/function but not allergic predisposition.
Authors:
Katharine C Pike; Hazel M Inskip; Sian M Robinson; Cyrus Cooper; Keith M Godfrey; Graham Roberts; Jane S A Lucas;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-03
Journal Detail:
Title:  Thorax     Volume:  68     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-08     Completed Date:  2013-07-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  372-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adiposity
Asthma / epidemiology
Body Composition
Body Mass Index*
Child
Humans
Hypersensitivity
Infant
Mothers*
Obesity / epidemiology
Respiratory Sounds / physiopathology*
Risk Factors
Spirometry
Weight Gain*
Grant Support
ID/Acronym/Agency:
MC_U147574218//Medical Research Council; MC_U147585819//Medical Research Council; MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1017//Medical Research Council; RG/07/009/23120//British Heart Foundation; SP/02/003/14542//British Heart Foundation
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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