Document Detail

The relationship between the locomotor response to a novel environment and behavioral disinhibition in rats.
MedLine Citation:
PMID:  17997051     Owner:  NLM     Status:  MEDLINE    
Behavioral disinhibition, a component of impulsivity, has been associated with cocaine abuse and dependence. To examine the relationship between behavioral disinhibition and vulnerability to cocaine use disorders, we employed the high responder (HR)/low responder (LR) rodent model, in which rats that exhibit high levels of activity in response to a novel environment are more sensitive to the effects of psychostimulants. In Experiment 1, performance under a differential reinforcement of low-rate (DRL) schedule was used as a measure of behavioral disinhibition in HR and LR rats. The HR rats displayed more behavioral disinhibition relative to LR rats on the DRL 20- and 35-s schedules. In Experiment 2, rats were divided into groups with high disinhibition (HD) and low disinhibition (LD) based on DRL 20-s performance, then challenged with cocaine. Rats characterized as HD and LD had similar DRL 20-s performance to rats characterized as HR and LR (Experiment 1), respectively, but did not differ in their response to cocaine. The results of this study suggest that the HR phenotype may also be characterized by greater behavioral disinhibition, and that the DRL task is a suitable animal model to investigate the role of behavioral disinhibition in vulnerability to the behavioral effects of cocaine.
Erin C Stoffel; Kathryn A Cunningham
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-09
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  92     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  69-78     Citation Subset:  IM    
Center for Addiction Research, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 300 University Boulevard, Galveston, TX 77555-1031, USA.
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MeSH Terms
Behavior, Animal / drug effects*
Central Nervous System Stimulants / pharmacology
Cocaine / pharmacology
Conditioning, Operant / drug effects
Data Interpretation, Statistical
Dopamine Uptake Inhibitors / pharmacology
Impulsive Behavior / psychology
Motor Activity / drug effects*,  physiology*
Rats, Sprague-Dawley
Reinforcement (Psychology)
Grant Support
F32 DA 0121438/DA/NIDA NIH HHS; K02 DA000260/DA/NIDA NIH HHS; K05 DA 020087/DA/NIDA NIH HHS; R01 DA 006511/DA/NIDA NIH HHS; T32 DA 07287/DA/NIDA NIH HHS
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine

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