| The relationship between leptin concentrations, the systemic inflammatory response and illness severity in surgical patients admitted to ITU. | |
| | |
MedLine Citation:
|
PMID: 15030963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND & AIMS: The relationship between circulation leptin concentrations, mediators of the systemic inflammatory response and illness severity in critically ill patients remains unclear. The aim of the present study was to examine these relationships in critically ill surgical patients admitted to the intensive therapy unit (ITU). PATIENTS AND METHODS: Patients (n = 38) who had undergone surgery and subsequently admitted to ITU were prospectively entered into a cross-sectional study. Circulating concentrations of leptin, cortisol, growth hormone, interleukin-6, C-reactive protein and albumin were measured. Sex and age matched controls (n = 14) were also studied. RESULTS: On day 1, the critically ill group had lower BMI and leptin concentrations and a pronounced systemic inflammatory response compared with controls. There was a weak positive correlation between leptin concentrations and BMI in the critically ill patients (r = 0.42, P<0.10). In contrast, leptin was inversely correlated with C-reactive protein (r = -0.59, P<0.05) but not with cortisol, growth hormone, interleukin-6, APACHE II or predicted mortality. Leptin concentrations did not alter with the day of admission to ITU. CONCLUSIONS: On ITU admission, leptin concentrations appeared to be low for BMI, related to the magnitude of the systemic inflammatory response but did not appear to be regulated by proposed mediators in critically ill surgical patients. |
| | |
Authors:
|
Tara Quasim; Donald C McMillan; A Michael Wallace; John Kinsella |
Related Documents
:
|
6767453 - Complement, opsonins, and the immune response to bacterial infection in burned patients. 21289623 - Abcb1 single-nucleotide polymorphisms determine tacrolimus response in patients with ul... 21741663 - Subjective emotional experience at different stages of parkinson's disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: 23 ISSN: 0261-5614 ISO Abbreviation: Clin Nutr Publication Date: 2004 Apr |
Date Detail:
|
Created Date: 2004-03-19 Completed Date: 2004-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: Scotland |
Other Details:
|
Languages: eng Pagination: 233-8 Citation Subset: IM |
Affiliation:
|
University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Body Mass Index Critical Illness Female Humans Inflammation / blood* Intensive Care Units* Leptin / blood* Male Middle Aged Postoperative Care Respiration, Artificial Severity of Illness Index* |
| Chemical | |
Reg. No./Substance:
|
0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Malnutrition in critically ill children: from admission to 6 months after discharge.
Next Document: Weight stabilisation is associated with improved survival duration and quality of life in unresectab...